123237-62-7Relevant articles and documents
Studies toward the Synthesis of an Oxazole-Based Analog of (-)-Zampanolide
Bold, Christian P.,Klaus, Cindy,Pfeiffer, Bernhard,Schurmann, Jasmine,Lombardi, Rafael,Lucena-Agell, Daniel,Diaz, J. Fernando,Altmann, Karl-Heinz
, p. 2238 - 2242 (2021/04/05)
Studies are described toward the synthesis of an oxazole-based analog of (-)-zampanolide (2). Construction of (-)-dactylolide analog 22 was achieved via alcohol 5 and acid 4 through esterification and Horner-Wadsworth-Emmons (HWE)-based macrocyclization; however, attempts to attach (Z,E)-sorbamide to 22 proved unsuccessful. The C(8)-C(9) double bond of the macrocycle was prone to migration into conjugation with the oxazole ring, which may generally limit the usefulness of zampanolide analogs with aromatic moieties as tetrahydropyran replacements.
Synthesis of acylglycerol derivatives by mechanochemistry
Ardila-Fierro, Karen J.,Pich, Andrij,Spehr, Marc,Hernández, José G.,Bolm, Carsten
supporting information, p. 811 - 817 (2019/04/17)
In recent times, many biologically relevant building blocks such as amino acids, peptides, saccharides, nucleotides and nucleosides, etc. have been prepared by mechanochemical synthesis. However, mechanosynthesis of lipids by ball milling techniques has remained essentially unexplored. In this work, a multistep synthetic route to access mono- and diacylglycerol derivatives by mechanochemistry has been realized, including the synthesis of diacylglycerol-coumarin conjugates.
Synthesis method of glycerol carbonate
-
Paragraph 0041; 0042; 0043, (2017/10/13)
The invention relates to the field of glycerol carbonate, particularly a synthesis method of high-purity glycerol carbonate. According to the method, glycidol is utilized to prepare the high-purity glycerol carbonate. The method comprises the following steps: adding glycidol, triethylamine and dichloromethane into a reaction kettle, performing cooling to 0 DEG C, dropwisely adding a silyl protecting group, recovering to room temperature after the dropwise addition is finished, performing reaction over night, performing washing with water, drying and distillation to obtain silyl-protected glycidol, performing addition reaction with carbon dioxide by using a catalyst to obtain silyl-protected glycerol carbonate, performing deprotection by using an acid, and performing distillation to remove the solvent, thereby obtaining the high-purity glycerol carbonate. The method has the advantages of simple technical operation process, recyclable raw materials, high product purity and low hazard, and is suitable for industrial production.
