123251-49-0

Basic information

• Product Name: bis[2-(N,N-diethylaminocarbonyl)phenyl] diselenide
• Synonyms: bis[2-(N,N-diethylaminocarbonyl)phenyl] diselenide
• CAS NO: 123251-49-0
• Molecular Weight: 510.397
• Mol File: 123251-49-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: bis[2-(N,N-diethylaminocarbonyl)phenyl] diselenide(CAS DataBase Reference)
• NIST Chemistry Reference: bis[2-(N,N-diethylaminocarbonyl)phenyl] diselenide(123251-49-0)
• EPA Substance Registry System: bis[2-(N,N-diethylaminocarbonyl)phenyl] diselenide(123251-49-0)

Safety Data

• Hazardous Substances Data: 123251-49-0(Hazardous Substances Data)

Upstream product

• 76041-87-7 N,N-diethyl-2-iodobenzamide 
• 105893-07-0 2,2’-diselanediyldibenzoyl chloride 
• 109-89-7 diethylamine 
• 1441-85-6 2-(chloroseleno)benzoyl chloride 
• 1696-17-9 N,N-diethylbenzamide 

Downstream Products

• 1161746-69-5 C₁₇H₁₉NOSSe 
• 4734-58-1 selenoxanthen-9-one 

Relevant articles and documents

Copper catalyzed/mediated synthetic methodology for ebselen and related isoselenazolones

Scope of the copper catalyzed/mediated selenium-nitrogen coupling reaction has been studied for the synthesis of isoselenazolones. It is noticed that the 2-chloro, 2-bromo-, and 2-iodo-aryl amides substrates can be exploited in the selenium-nitrogen coupling reaction by employing 25-100 mol % of CuI/1,10-phenanthroline (L) and potassium carbonate as a base in DMF. Furthermore, electron rich 2-chloro-arylamides also underwent selenium-nitrogen coupling reaction to give biologically important selenium-nitrogen heterocycles. Also, copper-catalyzed selenium-nitrogen coupling reaction has been meticulously applied for the synthesis of diaryl diselenides having methoxy, amine, and amide functionality from respective aryl iodides in the presence of stoichiometric amount of succinimide as an external Se-N coupling partner.

Bisbenzisoselenazol-3(2H)-ones, a new group of ebselen analogues

The title compounds with benzisoselenazolone moieties connected by spacers such as phenylene, bisphenylene, alkylene, oxaalkylene, azaalkylene and dithiaalkylene groups have been obtained in the reaction of 2-(chloroseleno)benzoyl chloride with compounds having two primary amine groups, while the secondary amines gave products of their selenenylation and/or acylation. Bisbenzisoselenazol-3(2II)-ones were found, in the antiviral assay in vitro, to be inhibitors of cytopathic activity of RNA and DNA viruses: EMCV, HSV-1 and VSV.