1232660-55-7Relevant articles and documents
Microwave-promoted copper-free Sonogashira-Hagihara couplings of aryl imidazolylsulfonates in water
Civicos, Jose F.,Alonso, Diego A.,Najera, Carmen
supporting information, p. 203 - 208 (2013/03/14)
Aryl imidazol-1-ylsulfonates have been efficiently cross-coupled with aryl-, alkyl-, and silylacetylenes in neat water under copper-free conditions at 110 °C assisted by microwave irradiation. Using 0.5mol% of an oxime palladacycle as precatalyst, 2-dicyclohexylphosphino-2′,6′- dimethoxybiphenyl (SPhos, 2mol%) as ligand, hexadecyltrimethylammonium bromide (CTAB) as additive, and triethylamine (TEA) as base, a wide array of disubstituted alkynes has been prepared in good to high yields in only 30min. Copyright
