1232693-01-4Relevant articles and documents
Amino acid-promoted C-H alkylation with alkylboronic acids using a removable directing group
Zhang, Yanghui,Zhang, Yu,Jiang, Hang,Chen, Dushen
, p. 4585 - 4589 (2016/06/09)
Palladium-catalyzed C-H alkylation reaction with alkylboronic acids has successfully been developed using a removable pyridyldiisopropylsilyl directing group. The amino acid played a crucial role as a ligand in the reaction. The alkylation protocol is also applicable to the coupling of C(sp3)-H bonds with alkylboronic acids.
PyDipSi: A general and easily modifiable/traceless Si-tethered directing group for C-H acyloxylation of arenes
Chernyak, Natalia,Dudnik, Alexander S.,Huang, Chunhui,Gevorgyan, Vladimir
supporting information; experimental part, p. 8270 - 8272 (2010/08/04)
A new general and easily installable silicon-tethered pyridyl-containing directing group (PyDipSi) that allows for highly efficient and regioselective Pd-catalyzed ortho C-H acyloxylation of arenes has been developed. It has also been demonstrated that this directing group can efficiently be removed as well as converted into a variety of other valuable functional groups. In addition, the installation of the PyDipSi directing group along with pivaloxylation and quantitative conversion of the PyDipSi group into a halogen functionality represents a formal three-step ortho oxygenation of haloarenes.