7751-38-4 Usage
Physical properties
bp 50–55°C/5 mmHg.
Uses
Dichlorodiisopropylsilane can be used in nucleoside 3',5'-hydroxy protection; component in Peterson
alkenation reaction.The use of silicon groups as
protection for hydroxy groups has been widely exploited.3 One
potentially useful way to protect a nucleoside is by using a protecting
group which spans the 3- and 5-hydroxy groups. One of
the useful groups which can be used as a bifunctional protecting
group in nucleosides is the diisopropylsilyl group. Reaction of the
nucleoside with dichlorodiisopropylsilane and imidazole in DMF
gives the protected nucleoside (eq 1).This method has not been widely used; the more common 3',5'-hydroxy-bridging protecting
group is a tetraisopropyldisiloxy group.
Preparation
conveniently prepared by the reaction of diisopropylsilane
in carbon tetrachloride with palladium(II) chloride
at 140°C for 8 h in a steel bomb.Washing the residue with
ether and removing the ether by rotary evaporation yields the
product which is purified by distillation to yield a clear colorless
oil.
Check Digit Verification of cas no
The CAS Registry Mumber 7751-38-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,7,5 and 1 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 7751-38:
(6*7)+(5*7)+(4*5)+(3*1)+(2*3)+(1*8)=114
114 % 10 = 4
So 7751-38-4 is a valid CAS Registry Number.
InChI:InChI=1/C6H14Cl2Si/c1-5(2)9(7,8)6(3)4/h5-6H,1-4H3
7751-38-4Relevant articles and documents
Versatile method for introduction of bulky substituents to alkoxychlorosilanes
Masaoka, Shin,Banno, Tadashi,Ishikawa, Mitsuo
, p. 182 - 192 (2007/10/03)
The reactions of various alkoxytrichlorosilanes prepared in situ from tetrachlorosilane and alcohols, with Grignard reagents bearing a bulky substituent such as the isopropyl, sec-butyl, and cyclohexyl group afforded triisopropyl-, tri(sec-butyl)-, and tricyclohexylalkoxysilane in high yields. The reactions of n-butoxytrichlorosilane with these Grignard reagents produced triisopropyl-, tri(sec-butyl)-, and tricyclohexyl(n-butoxy)silane in 94%, 96%, and 92% yields, respectively. Methoxymethyldichlorosilane reacted with the same Grignard reagents to give diisopropyl-, di(sec-butyl)-, and dicyclohexylmethoxymethylsilane in 84%, 83%, and 83% yields. Treatment of methoxydimethylchlorosilane with the Grignard reagents readily afforded isopropyl-, sec-butyl-, and cyclohexylmethoxydimethylsilane in excellent yields. Similar treatment of methoxydimethylchlorosilane with tert-butylmagnesium chloride gave tert-butylmethoxydimethylsilane in 62% yield.
