123284-47-9

Upstream product

• 7417-21-2 2-(3,4-dimethoxyphenyl)ethyl alcohol 
• 132283-68-2 2-(2-chloroethyl)-4,5-dimethoxybenzaldehyde 
• 123190-11-4 1-bromoisochroman 
• 123190-12-5 2-(2-bromoethyl)-4,5-(dimethoxy)benzaldehyde 
• 20989-17-7 (2S)-2-phenylglycinol 
• 153073-85-9 (1'S)-6,7-dimethoxy-2-2'-hydroxy-1'-phenylethyl-1,2,3,4-tetrahydroisoquinoline 
• 20780-53-4 (R)-Styrene oxide 
• 1745-07-9 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 123190-15-8 2-((S)-2-Hydroxy-1-phenyl-ethyl)-6,7-dimethoxy-3,4-dihydro-isoquinolinium; bromide 
• 132283-67-1 6,7-dimethoxy-1-ethoxyisochroman 

Downstream Products

• 123190-13-6 (1S,1'S)-6,7-dimethoxy-2-(2-hydroxy-1-phenylethyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline 
• 170710-98-2 (S)-2-((S)-6,7-Dimethoxy-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-2-phenyl-ethanol 

Relevant academic research and scientific papers

β-AMINO ALCOHOL-N-OXIDES AS PRECURSORS OF CHIRAL OXAZOLIDINES: SYNTHESIS OF (R)-(-)-CRYPTOSTYLINE I

The access to chiral oxazolotetrahydroquinoline by base deprotonation of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-N-oxide, allowed the synthesis of (R)-(-)-cryptostyline I.

SYNTHESES OF CHIRAL OXAZOLOTETRAHYDROISOQUINOLINE AND ITS ASYMMETRIC ALKYLATION. SYNTHESIS OF (S)-(-)- AND (R)-(+)-SALSOLIDINES

The isoquinolinium bromide (4), on treatment with base, underwent cyclization to give the chiral oxazolotetrahydroisoquinoline (5) with a high diastereoselectivity, which was converted to optically pure salsolidine.