1232954-21-0

Basic information

• Product Name: 3-benzyl-1-tosylpiperidin-2-one
• Synonyms: 3-benzyl-1-tosylpiperidin-2-one
• CAS NO: 1232954-21-0
• Molecular Weight: 343.447
• Mol File: 1232954-21-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-benzyl-1-tosylpiperidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-benzyl-1-tosylpiperidin-2-one(1232954-21-0)
• EPA Substance Registry System: 3-benzyl-1-tosylpiperidin-2-one(1232954-21-0)

Safety Data

• Hazardous Substances Data: 1232954-21-0(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 675-20-7 piperidin-2-one 
• 53031-80-4 3-benzylidene-piperidin-2-one 

Downstream Products

• 1232954-23-2 3-benzyl-3-(difluoroiodomethyl)-1-tosyl-piperidin-2-one 
• 1598387-07-5 3-benzyl-3-difluoro(trimethylsilyl)methyl-1-tosylpiperidin-2-one 
• 1364569-63-0 3-benzyl-3-(difluoromethyl)-1-tosylpiperidin-2-one 

Relevant articles and documents

Gold(I)-Catalysed Hydroarylation of Lactam-Derived Enynes as an Entry to Tetrahydrobenzo[g]quinolines

The gold(I)-catalysed cyclization of N-tosyl-protected 5-benzyl-6-((trimethylsilyl)ethynyl)-1,2,3,4-tetrahydropyridines, prepared by the Sonogashira coupling of lactam-derived enol triflates, provides tetrahydrobenzo[g]quinolines whose skeleton represents a recurrent motif in natural compounds. The Au(I)-catalysed reaction is carried out with (C6F5)3PAuCl/AgNTf2 as the catalyst system and proceeds via a 6-exo-dig cyclization to form an exocyclic double bond, which eventually isomerises to the aromatic tetrahydrobenzo[g]quinoline. The mode of cyclization is discussed and supported by DFT calculations.