1233025-55-2Relevant academic research and scientific papers
A PROCESS FOR THE PREPARATION OF CRYSTALLINE FORM 1 OR CLOPIDOGREL HYDROGEN SULFATE
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Page 16 - 17, (2008/06/13)
The crystalline Form 1 of methyl (S)-clopidogrel hydrogen sulfate is prepared by precipitating the salt formed in the reaction of the optically active base, methyl (S) - (+) -α- (2-chlorophenyl) -4, 5, 6, 7-tetrahydrothieno[3,2-c]pyridine-5-acetate with c
Novel crystal forms III, IV, V, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form I, compositions containing the new forms and methods of administering the new forms
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, (2008/06/13)
The present invention provides new crystalline Forms III, IV and V of clopidogrel hydrogensulfate and the amorphous form of clopidogrel hydrogensulfate, as well as their pharmaceutical compositions, and method of treatments with such compositions. The present invention also provides novel processes for preparation of clopidogrel hydrogensulfate Form I, Form III, Form IV, Form V and the amorphous form. The present invention further provides a novel process where the amorphous form is converted to Form I by contacting Form I with an ether.
