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High purity 113665-84-2 Clopidogrel
Cas No: 113665-84-2
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
113665-84-2 Clopidogrel
Cas No: 113665-84-2
USD $ 40.0-50.0 / Gram 1 Gram 1000 Metric Ton/Day WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
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Cas No: 113665-84-2
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Cas No: 113665-84-2
USD $ 23.0-23.8 / Gram 500 Gram 100000 Kilogram/Year Xi'an Quanao Biotech Co., Ltd. Contact Supplier
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Cas No: 113665-84-2
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
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USD $ 1.0-1.0 / Metric Ton 1 Metric Ton 3000 Metric Ton/Year Henan Sinotech Import&Export Corporation Contact Supplier
Clopidogrel 113665-84-2
Cas No: 113665-84-2
No Data 1 Kilogram 10 Metric Ton/Month Henan Tianfu Chemical Co., Ltd. Contact Supplier
White Crystal Anticoagulant Drugs Clopidogrel Medication 113665-84-2
Cas No: 113665-84-2
USD $ 1.0-2.0 / Gram 10 Gram 12 Kilogram/Day Hubei Jusheng Technology Co., Ltd., Contact Supplier

113665-84-2 Usage

Brand name

Plavix (Sanofi Aventis).

Uses

Sertraline metabolite

Uses

anthelmintic, antiparasitic, antimite

113665-84-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name clopidogrel

1.2 Other means of identification

Product number -
Other names Clopidogrelum

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:113665-84-2 SDS

113665-84-2Synthetic route

methyl-(S)-alpha-(2-chlorophenyl)-6,7-dihydro-thieno[3,2-c]pyridine-5(4H)-acetate camphor sulphonate

methyl-(S)-alpha-(2-chlorophenyl)-6,7-dihydro-thieno[3,2-c]pyridine-5(4H)-acetate camphor sulphonate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane; water Product distribution / selectivity;100%
With sodium hydrogencarbonate In dichloromethane; water at 15 - 20℃; pH=7 - 8; Product distribution / selectivity;
With sodium hydrogencarbonate In chloroform; water for 2h;
(S)-(+)-clopidogrel bisulfate
120202-66-6

(S)-(+)-clopidogrel bisulfate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane; water at 15℃; for 0.333333h;100%
With ammonia In hexane; water at 25 - 30℃; pH=7;97.86%
With sodium carbonate In dichloromethane; water at 20℃; for 0.5h; Large scale;92%
clopidogrel camphorsulfonate
909279-85-2

clopidogrel camphorsulfonate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With sodium carbonate In tert-butyl methyl ether; water at 20℃; for 0.5h; Solvent;100%
With sodium hydrogencarbonate In dichloromethane; water at 25 - 30℃; for 0.166667h; Product distribution / selectivity;
With potassium carbonate In dichloromethane; water for 1h; pH=9; Product distribution / selectivity; cooling with cool salt water;
clopidogrel camphorsulfonate

clopidogrel camphorsulfonate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With sodium carbonate In tert-butyl methyl ether; water for 0.5h; Solvent;100%
With sodium hydrogencarbonate In acetone for 6h; Reflux;
clopidogrel (1R)-(-)-camphor-10-sulfonate

clopidogrel (1R)-(-)-camphor-10-sulfonate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane at 0 - 5℃; for 1h;99.2%
With potassium carbonate In dichloromethane; water for 0.5h;99%
With water; sodium hydrogencarbonate In dichloromethane at 0℃; Product distribution / selectivity;96%
(S)-(+)-α-(2-thienylethylamino)-α-(2-chlorophenyl)acetic acid methyl ester hydrochloride

(S)-(+)-α-(2-thienylethylamino)-α-(2-chlorophenyl)acetic acid methyl ester hydrochloride

formaldehyd
50-00-0

formaldehyd

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
at 40℃; for 4h; Darkness;98%
With hydrogenchloride In water at 20 - 80℃; for 2h;83.57%
Stage #1: (S)-(+)-α-(2-thienylethylamino)-α-(2-chlorophenyl)acetic acid methyl ester hydrochloride; formaldehyd In water at 25 - 30℃; for 20 - 24h;
Stage #2: With sodium carbonate In dichloromethane; water at 12 - 15℃; for 0.75 - 3.25h; pH=7.01 - 7.32; Product distribution / selectivity;
C15H13ClO5S

C15H13ClO5S

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With sodium carbonate In dichloromethane at 25 - 40℃; for 24h; Temperature;97.02%
SR 26334
144457-28-3

SR 26334

methanol
67-56-1

methanol

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
Stage #1: SR 26334 With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at -10 - 0℃; for 2.5h;
Stage #2: methanol In dichloromethane at 0 - 20℃; for 2.5h;
96%
Stage #1: SR 26334; methanol With acetyl chloride Heating / reflux;
Stage #2: With sodium hydroxide In water; ethyl acetate pH=7 - 8; Product distribution / selectivity;
91%
Stage #1: SR 26334; methanol With thionyl chloride at 70℃; for 6h;
Stage #2: With sodium hydrogencarbonate In water pH=7; Product distribution / selectivity;
88%
methanol
67-56-1

methanol

(S)-(+)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride
144750-42-5

(S)-(+)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
Stage #1: (S)-(+)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at -10 - 0℃; for 2.5h;
Stage #2: methanol In dichloromethane at 0 - 20℃; for 2.5h;
95%
Stage #1: methanol; (S)-(+)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride; sulfuric acid Heating / reflux;
Stage #2: With sodium hydroxide In water; ethyl acetate pH=8; Product distribution / selectivity;
Stage #1: methanol; (S)-(+)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride; sulfuric acid Heating / reflux;
Stage #2: With calcium hydroxide; sodium hydroxide In water pH=8; Product distribution / selectivity;
(+) clopidogrel (-) camphor sulfate

(+) clopidogrel (-) camphor sulfate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane pH=8; Conversion of starting material;95%
With potassium carbonate In dichloromethane; water pH=8; Conversion of starting material;
methanol
67-56-1

methanol

2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)acetonitrile
444728-11-4

2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)acetonitrile

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide for 12h; Reflux;95%
clopidogrel besylate

clopidogrel besylate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With sodium hydroxide In dichloromethane; water95%
methanol
67-56-1

methanol

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
Stage #1: (S)-(+)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride With dmap; triethylamine; methyl chloroformate In ethyl acetate at 20 - 30℃; for 1h;
Stage #2: methanol In ethyl acetate at 20℃; for 2h; Product distribution / selectivity;
92%
Stage #1: (S)-(+)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride With dmap; triethylamine; methyl chloroformate In dichloromethane at 20 - 30℃; for 1h;
Stage #2: methanol In dichloromethane at 20℃; for 2h; Product distribution / selectivity;
90%
Stage #1: SR 26334 With triethylamine; methyl chloroformate In dichloromethane at 20 - 30℃; for 1h;
Stage #2: methanol In dichloromethane at 20℃; for 2h; Product distribution / selectivity;
86%
Stage #1: C15H14ClNO2S*C19H22N2O With hydrogenchloride In water pH=4;
Stage #2: methanol With thionyl chloride In water at 70℃; for 6h;
Stage #3: With sodium hydrogencarbonate In water pH=7; Product distribution / selectivity;
60%
methyl (S)-2-(2-chlorophenyl)-2-[2-(thien-2-yl)ethylamino]acetate
141109-20-8

methyl (S)-2-(2-chlorophenyl)-2-[2-(thien-2-yl)ethylamino]acetate

formaldehyd
50-00-0

formaldehyd

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With sulfuric acid In dichloromethane at 0 - 25℃;91.4%
Stage #1: methyl (S)-2-(2-chlorophenyl)-2-[2-(thien-2-yl)ethylamino]acetate; formaldehyd In water at 60℃; for 0.333333 - 0.5h;
Stage #2: With sodium hydrogencarbonate In dichloromethane; water pH=7 - 8; Product distribution / selectivity;
63%
Stage #1: methyl (S)-2-(2-chlorophenyl)-2-[2-(thien-2-yl)ethylamino]acetate; formaldehyd With sodium hydrogencarbonate; potassium iodide In 1,2-dichloro-ethane for 4h; Reflux;
Stage #2: With hydrogenchloride In 1,2-dichloro-ethane; N,N-dimethyl-formamide at 30℃; Reflux;
50%
SR 26334
144457-28-3

SR 26334

dimethyl sulfate
77-78-1

dimethyl sulfate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With sodium hydroxide; tetrabutylammomium bromide In dichloromethane; water at 0 - 20℃; for 12h; Product distribution / selectivity;89%
SR 26334
144457-28-3

SR 26334

methyl iodide
74-88-4

methyl iodide

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide for 5h; Product distribution / selectivity;88%
2-(2-bromoethyl)-3-(bromomethyl)thiophene
865187-82-2

2-(2-bromoethyl)-3-(bromomethyl)thiophene

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt
213018-92-9

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 8.5h; Product distribution / selectivity; Heating / reflux;88%
With N-ethyl-N,N-diisopropylamine In tert-butyl alcohol for 8.5h; Product distribution / selectivity; Heating / reflux;85%
With potassium carbonate In acetonitrile for 8.5h; Product distribution / selectivity; Heating / reflux;78%
With triethylamine In acetonitrile for 8.5h; Product distribution / selectivity; Heating / reflux;41%
2-(2-chloroethyl)-3-chloromethylthiophene

2-(2-chloroethyl)-3-chloromethylthiophene

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt
213018-92-9

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 8.5h; Product distribution / selectivity; Heating / reflux;85%
6,7-dihydro-4H-thieno[3,2-c]pyran
865187-86-6

6,7-dihydro-4H-thieno[3,2-c]pyran

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt
213018-92-9

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
Stage #1: 6,7-dihydro-4H-thieno[3,2-c]pyran With dibromotriphenylphosphorane In acetonitrile for 24h; Heating / reflux;
Stage #2: (S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt With N-ethyl-N,N-diisopropylamine In acetonitrile for 8.5h; Product distribution / selectivity; Heating / reflux;
81%
2-(3-hydroxymethylthiophen-2-yl)ethanol
865187-81-1

2-(3-hydroxymethylthiophen-2-yl)ethanol

methyl (S)-(+)-2-amino-2-(2-chlorophenyl)acetate
141109-14-0

methyl (S)-(+)-2-amino-2-(2-chlorophenyl)acetate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; Bis(p-nitrophenyl) phosphate In toluene at 100℃; for 36h; Solvent; Time; Temperature; Sealed tube; Molecular sieve; Green chemistry;80%
2-(thiophen-2-yl)ethyl methanesulfonate
61380-07-2

2-(thiophen-2-yl)ethyl methanesulfonate

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt
213018-92-9

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 8.5h; Product distribution / selectivity; Heating / reflux;79%
methanol
67-56-1

methanol

(+)-α-(4,5,6,7-tetrahydrothieno[3,2-c]-5-pyridyl)-α-2-chlorophenylacetamide
444728-13-6

(+)-α-(4,5,6,7-tetrahydrothieno[3,2-c]-5-pyridyl)-α-2-chlorophenylacetamide

dimethyl sulfate
77-78-1

dimethyl sulfate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
Stage #1: methanol; dimethyl sulfate With sulfuric acid at 25 - 38℃; for 3h; Heating / reflux;
Stage #2: (+)-α-(4,5,6,7-tetrahydrothieno[3,2-c]-5-pyridyl)-α-2-chlorophenylacetamide at 40 - 66℃; for 60h;
73%
(R)-2-(2-chlorophenyl)-2-(4-nitrobenzenesulfonyloxy)acetic acid methyl ester

(R)-2-(2-chlorophenyl)-2-(4-nitrobenzenesulfonyloxy)acetic acid methyl ester

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
28783-41-7

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With potassium carbonate In dichloromethane; water for 2.5h; Reflux;70%
2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt
213018-92-9

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 8.5h; Product distribution / selectivity; Heating / reflux;58%
sodium (S)-(2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-acetate
929250-04-4

sodium (S)-(2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-acetate

dimethyl sulfate
77-78-1

dimethyl sulfate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With PEG400; sodium hydrogencarbonate In water; butan-1-ol at 10 - 40℃; for 31h; pH=~ 10; Product distribution / selectivity;51%
With sodium hydrogencarbonate; PEG 400 In water; butan-1-ol at 10 - 40℃; for 31h; pH=10; Product distribution / selectivity;51%
potassium (S)-(2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-acetate
929250-05-5

potassium (S)-(2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-acetate

dimethyl sulfate
77-78-1

dimethyl sulfate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With PEG400; sodium hydrogencarbonate In water; butan-1-ol at 10 - 40℃; for 31h; pH=~ 10; Product distribution / selectivity;51%
With sodium hydrogencarbonate; PEG 400 In water; butan-1-ol at 10 - 40℃; for 31h; pH=10; Product distribution / selectivity;51%
methyl 2-chloro-2-(2-chlorophenyl)acetate
90055-47-3

methyl 2-chloro-2-(2-chlorophenyl)acetate

4,5,6,7-tetrahydrothieno[3,2-c]pyridine
54903-50-3

4,5,6,7-tetrahydrothieno[3,2-c]pyridine

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 4h;45%
(S)-(+)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride
144750-42-5

(S)-(+)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride

methyl iodide
74-88-4

methyl iodide

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With potassium carbonate In 1-methyl-pyrrolidin-2-one Product distribution / selectivity;
methyl α-5(4,5,6,7-tetrahydro(3,2-c)thieno pyridyl) (2-chlorophenyl)-acetate isopropylsulfate

methyl α-5(4,5,6,7-tetrahydro(3,2-c)thieno pyridyl) (2-chlorophenyl)-acetate isopropylsulfate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; toluene Purification / work up;
5-sulfosalicylic Acid
97-05-2

5-sulfosalicylic Acid

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

methyl (+)-(S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate 5-sulfosalicylate
1010080-15-5

methyl (+)-(S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate 5-sulfosalicylate

Conditions
ConditionsYield
In methanol at 30℃; for 0.5h;100%
In dichloromethane at 20℃; for 0.5 - 1h; Product distribution / selectivity; Heating / reflux;100%
methanesulfonic acid
75-75-2

methanesulfonic acid

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

clopidogrel mesylate

clopidogrel mesylate

Conditions
ConditionsYield
In methanol at 5 - 35℃; for 12h;99.67%
In methanol for 36h; Heating / reflux;
In acetone for 2 - 10h; Heating / reflux;
In methanol for 2 - 10h; Heating / reflux;
(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

(S)-(+)-clopidogrel bisulfate
120202-66-6

(S)-(+)-clopidogrel bisulfate

Conditions
ConditionsYield
With sulfuric acid In ethyl acetate at -5 - 30℃; for 3h; Temperature; Solvent;99%
With sulfuric acid In ethyl acetate at -5 - 30℃; for 3h; Temperature; Solvent; Concentration; Inert atmosphere;99%
With polyethylene glycol-200; sulfuric acid; sodium hydrogencarbonate In acetone at -5 - 20℃; for 0.0833333 - 0.116667h; pH=8; Conversion of starting material;96%
(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

clopidogrel hydrobromide

clopidogrel hydrobromide

Conditions
ConditionsYield
With hydrogen bromide In water; ethyl acetate at 10 - 15℃; for 1h; Product distribution / selectivity;98%
With hydrogen bromide In tetrahydrofuran; water at 20℃; Product distribution / selectivity;80%
With water; hydrogen bromide In dichloromethane; di-isopropyl ether; isopropyl alcohol at 20 - 27℃; for 3.66667h;80%
(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

methyl (R)-2-(2-chlorophenyl)-2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)acetate
120202-69-9

methyl (R)-2-(2-chlorophenyl)-2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)acetate

clopidogrel
90055-48-4

clopidogrel

Conditions
ConditionsYield
With potassium carbonate In methanol for 3h; Product distribution / selectivity; Heating / reflux;96%
With sodium hydrogencarbonate In methanol for 3h; Product distribution / selectivity; Heating / reflux;94%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In methanol for 3h; Product distribution / selectivity; Heating / reflux;92%
(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

C16H13(2)H3ClNO2S

C16H13(2)H3ClNO2S

Conditions
ConditionsYield
With [(2)H6]acetone; tris(pentafluorophenyl)borate In toluene at 150℃; for 6h; Inert atmosphere;94%
benzenesulfonic acid
98-11-3

benzenesulfonic acid

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

clopidogrel besylate

clopidogrel besylate

Conditions
ConditionsYield
In water; acetone at 0 - 5℃; for 1h; Solvent; Time;92.6%
In acetone for 2 - 10h; Heating / reflux;
In n-heptane at 20℃;
(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

C15H16ClNOS
1227294-01-0

C15H16ClNOS

Conditions
ConditionsYield
With lithium aluminium tetrahydride In diethyl ether at 20℃; for 20h;92%
(1S)-10-camphorsulfonic acid
3144-16-9

(1S)-10-camphorsulfonic acid

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

(+)-clopidogrel camphorsulfonic acid

(+)-clopidogrel camphorsulfonic acid

Conditions
ConditionsYield
In ethyl acetate at 20℃; for 12h;91%
In ethyl acetate at 0 - 20℃; for 4h; Product distribution / selectivity;
In acetone at 0 - 5℃; for 2h; Product distribution / selectivity; methyl (+)-(2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetic acid (1S)-(+)-camphor-10-sulfonate;
(1S)-(+)-10-camphorsulfonic acid

(1S)-(+)-10-camphorsulfonic acid

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

clopidogrel camphorsulfonate

clopidogrel camphorsulfonate

Conditions
ConditionsYield
In ethyl acetate at 0 - 20℃; for 5h; Product distribution / selectivity;90%
In di-isopropyl ether; acetone at 0 - 20℃; for 6h; Product distribution / selectivity;88%
In butanone at 0 - 20℃; for 4.5h; Product distribution / selectivity;86%
In 4-methyl-2-pentanone at 0 - 20℃; for 5h; Product distribution / selectivity;
(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

(S)-clopidogrel hydrogen sulfate
1233025-55-2

(S)-clopidogrel hydrogen sulfate

Conditions
ConditionsYield
With sulfuric acid In 1,2-dimethoxyethane at 0 - 5℃; for 12h;90%
With sulfuric acid In ethanol; tert-butyl methyl ether at 0 - 5℃; for 10.5h;90%
With sulfuric acid In acetone82%
naphthalene-1,5-disulfonate
81-04-9

naphthalene-1,5-disulfonate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

clopidogrel 1,5-naphthalenedisulfonate

clopidogrel 1,5-naphthalenedisulfonate

Conditions
ConditionsYield
In water; acetone at 0 - 20℃; for 16.5h;90%
naphthalene-1,5-disulfonate
81-04-9

naphthalene-1,5-disulfonate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

methyl (+)-(S)-α-(o-chlorophenyl)-6,7-dihydrothieno[3,2-a]pyridine-5(4H)acetate 1,5-naphthalenedisulfonate monohydrate

methyl (+)-(S)-α-(o-chlorophenyl)-6,7-dihydrothieno[3,2-a]pyridine-5(4H)acetate 1,5-naphthalenedisulfonate monohydrate

Conditions
ConditionsYield
With water In acetone at 0 - 20℃; for 16.5h; Product distribution / selectivity;90%
In 1,4-dioxane; ethanol
(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

methyl (+)-(S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-C]pyridine-5(4H)-acetate naphthalene-1,5-disulfonate

methyl (+)-(S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-C]pyridine-5(4H)-acetate naphthalene-1,5-disulfonate

Conditions
ConditionsYield
With naphthalene-1,5-disulfonate In water; acetone at 20℃; for 12.5h;90%
naphthalene-1,5-disulfonate
81-04-9

naphthalene-1,5-disulfonate

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

methyl (+)-(S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-C]pyridine-5(4H)-acetate naphthalene-1,5-disulfonate

methyl (+)-(S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-C]pyridine-5(4H)-acetate naphthalene-1,5-disulfonate

Conditions
ConditionsYield
In water; acetone at 0 - 20℃; for 16.5h;90%

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ResumenIntroducciónEl objetivo de este estudio fue recopilar datos retrospectivos sobre la prescripción de clopidogrel y describir las condiciones de uso en la población pediátrica de un hospital de referencia de nivel terciario y evaluarlas con base en la evidencia disponible.detailed

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IntroductionThe aim of this study was to collect retrospective data on the prescription of clopidogrel, describe the conditions of its use in the paediatric population of a tertiary referral hospital, and evaluate its use based on the current scientific evidence.detailed

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