1233114-22-1

Basic information

• Product Name: 3-[3-tert-butylsulfanyl-1-[4-(5-methoxypyrimidin-2-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid
• Synonyms: 3-[3-tert-butylsulfanyl-1-[4-(5-methoxypyrimidin-2-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid
• CAS NO: 1233114-22-1
• Molecular Weight: 624.804
• Mol File: 1233114-22-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-[3-tert-butylsulfanyl-1-[4-(5-methoxypyrimidin-2-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[3-tert-butylsulfanyl-1-[4-(5-methoxypyrimidin-2-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid(1233114-22-1)
• EPA Substance Registry System: 3-[3-tert-butylsulfanyl-1-[4-(5-methoxypyrimidin-2-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid(1233114-22-1)

Safety Data

• Hazardous Substances Data: 1233114-22-1(Hazardous Substances Data)

Usage

Molecular structure

The compound contains indole, benzyl, and pyrimidine moieties, as well as a tert-butylsulfanyl group and a 2,2-dimethylpropionic acid moiety.

Synthetic

It is a synthetic molecule.

Potential applications

The compound may have potential applications in research and drug development.

Further investigation needed

Specific properties and potential uses for this compound would require further investigation and analysis.

Upstream product

• 67-56-1 methanol 
• 1245899-92-6 C₃₇H₄₁FN₄O₃S 

Downstream Products

• 1233114-34-5 sodium 3-[3-tert-butylsulfanyl-1-[4-(5-methoxypyrimidin-2-yl)-benzyl]-5-(5-methyl-pyridin-2-yl-methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionate 

Relevant articles and documents

5-Lipoxygenase-activating protein inhibitors. Part 3: 3-{3-tert- Butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-5-(5-methyl-pyridin-2- ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM643) - A potent FLAP inhibitor suitable for topical administration

AM643 (compound 6, 3-{3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)- benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid) was identified as a potential candidate for formulation as a topical agent for the treatment of skin disorders involving leukotriene production. Dermal application of 6 using a prototypical vehicle in a murine ear arachidonic acid model showed significant reduction in the concentrations of leukotrienes in mouse skin with concomitant reduction in ear swelling.