123312-23-2

Upstream product

• 3179-09-7 (E)-1-methoxy-3-(2-nitrovinyl)benzene 
• 75-52-5 nitromethane 
• 874-98-6 1-bromomethyl-3-methoxybenzene 
• 152356-73-5 (Z)-1-(3-methoxyphenyl)-2-nitroethene 
• 3179-09-7 1-methoxy-3-(2-nitrovinyl)benzene 

Downstream Products

• 123312-24-3 1-methoxy-3-[1-(nitromethyl)propyl]benzene 
• 152356-74-6 tert-butyl 5-(3-methoxyphenyl)-4-nitrovalerate 
• 1255037-14-9 3-(3-methoxyphenyl)-2-nitropropan-1-ol 
• 123312-30-1 2-(2-Bromo-5-methoxy-phenyl)-N-[2-(3-methoxy-phenyl)-butyl]-acetamide 
• 123312-35-6 1-(2-Bromo-5-methoxy-benzyl)-4-ethyl-6-methoxy-1,2,3,4-tetrahydro-isoquinoline 
• 123312-25-4 2-(3-methoxyphenyl)-1-butanamine 

Relevant academic research and scientific papers

Reduction of α,β-unsaturated nitroolefins into nitroalkanes with Hantzsch ester promoted by isothiouronium salts

α,β-Unsaturated nitroolefins were reduced into nitroalkanes with a Hantzsch ester, promoted by S-benzyl isothiouronium iodide. The reactions proceeded successfully to afford the desired products in high yields and with excellent chemoselectivity.

Copper-Catalyzed Alkylation of Nitroalkanes with α-Bromonitriles: Synthesis of β-Cyanonitroalkanes

Copper catalysis now enables the efficient C-alkylation of nitroalkanes with α-bromonitriles. Using a simple and inexpensive catalyst, this process provides access to β-cyanonitroalkanes. The method is highly tolerant of various functional groups and substitution patterns. These functionally dense products serve as orthogonally masked 1,3-diamines, which can be revealed selectively for access to differentially substituted diamines. These products can also be exploited for the formation of complex cyanoalkenes and 5-aminoisoxazoles.

The highly chemoselective transfer hydrogenation of the carbon-carbon double bond of conjugated nitroalkenes by a rhodium complex

Chemoselective transfer hydrogenation of conjugated nitroalkenes catalyzed by [RhCl2Cp·]2-diamine complex (Cp ·=η5-C5Me5) using HCOOH/Et3N (5:2) (TEAF) as a hydrogen source was realized. A variety of nitrostyrenes, β-methyl nitrostyrenes, and 3-methyl-4-nitro-5-alkenyl- isoxazoles were reduced smoothly in good to excellent yields in short reaction time. Other functional groups are inert under the reaction conditions.

S-benzyl isothiouronium chloride as a recoverable organocatalyst for the reduction of conjugated nitroalkenes with Hantzsch ester

The reduction of conjugated nitroalkenes into nitroalkanes with Hantzsch ester using S-benzyl isothiouronium chloride as a recoverable organocatalyst was successfully accomplished with high yield and excellent chemoselectivity.

Ethanolamine derivatives having sympathomimetic and anti-pollakiuria activities

This invention relates to new ethanolamine derivatives having gut selective sympathomimetic and anti-pollakiuria activities and represented by the general formula [I]: STR1 wherein R1 is aryl or a heterocyclic group, each of which may be substituted with halogen, etc., R2 is hydrogen, halogen, nitro, hydroxy, lower alkyl optionally substituted with acyl, lower alkenyl optionally substituted with acyl, lower alkoxy optionally substituted with acyl, or amino optionally substituted with acyl(lower)alkyl, R3 is hydrogen, an N-protective group, or lower alkyl optionally substituted with lower alkylthio, n is an integer of 0 to 3, and a heavy solid line means a single bond or a double bond, provided that when n is 1, then 1) R1 is a condensed aromatic hydrocarbon group or a heterocyclic group, each of which may be substituted with halogen, etc., and the like, and pharmaceutically acceptable salts thereof to processes for the preparation thereof and to a pharmaceutical composition comprising the same.

REDUCTION OF AROMATIC NITROALKENES WITH BAKER'S YEAST

Aromatic nitroalkenes were reduced chemoselectively with baker's yeast to give the corresponding nitroalkanes.

Reduction of conjugated nitroalkenes with zinc borohydride. A mild method for converting monosubstituted nitroalkenes to nitroalkanes and disubstituted ones to oximes

Mono-β-substituted conjugated nitroalkenes are readily reduced by zinc borohydride in 1,2-dimethoxyethane to the corresponding nitroalkanes, whereas the disubstituted ones furnish the corresponding oximes in excellent yields.

Highly Selective Reduction of Conjugated Nitroalkenes with Zinc Borohydride in DME

Zinc borohydride in 1,2-dimethoxyethane reduces α-substituted conjugated nitroalkenes to the corresponding oximes and non-α-substituted ones to the corresponding nitroalkanes in excellent yields.

Indoloisoquinolines. Syntheses, Steroid Hormone Receptor Binding Affinities, and Cytostatic Activity

A number of acetoxy-substituted 5,6-dihydroindoloisoquinolines were synthesized and tested for binding affinity for steroid hormone receptors.All of the derivatives bind to the estrogen receptor with RBA values ranging from 1.5 to 17 (17β-estradiol

Selective Reduction of Carbon-Carbon Double Bonds with an NAD(P)H Model-Acetic Acid System

The carbon-carbon double bond in conjugated nitro and certain carbonyl compounds was reduced smoothly and selectively by Hantzsch ester (HEH), an NAD(P)H model, in the presence of a small amount of acetic acid.