123312-24-3

Upstream product

• 3179-09-7 (E)-1-methoxy-3-(2-nitrovinyl)benzene 
• 557-20-0 diethylzinc 
• 123312-23-2 2-(3-methoxyphenyl)-1-nitroethane 
• 75-03-6 ethyl iodide 
• 3179-09-7 1-methoxy-3-(2-nitrovinyl)benzene 
• 591-31-1 3-methoxy-benzaldehyde 

Downstream Products

• 123312-25-4 2-(3-methoxyphenyl)-1-butanamine 
• 123312-35-6 1-(2-Bromo-5-methoxy-benzyl)-4-ethyl-6-methoxy-1,2,3,4-tetrahydro-isoquinoline 
• 123312-30-1 2-(2-Bromo-5-methoxy-phenyl)-N-[2-(3-methoxy-phenyl)-butyl]-acetamide 

Relevant academic research and scientific papers

Application of the chiral bis(phosphine) monoxide ligand to catalytic enantioselective addition of dialkylzinc reagents to β-nitroalkenes

(Chemical Equation Presented) Me-DuPHOS monoxide is shown to be a very effective ligand in the enantioselective copper-catalyzed addition of dialkylzinc reagents to β-nitroalkenes providing access to chiral nitroalkanes. The major advantages of this process are high yields, broad and complementary substrate scope, and high enantioselectivities. The effect of achiral dummy ligands as an additive has also been documented.

Enantioselective Conjugate Addition of Primary Dialkylzinc Reagents to 2-Aryl- and 2-Heteroaryl-nitroolefins Mediated by Titanium-TADDOLates Preparation of Enantioenriched 2-Aryl-alkylamines

The addition of dialkylzinc to nitroolefins is catalyzed by Lewis acids such as MgBr2, MgI2, and chlorotitanates.Using the (R,R)-Ti-TADDOLates the addition of diethyl-, dibutyl-, and dioctyl zinc to 2-aryl-nitroethenes is shown to be enantioselective with

Indoloisoquinolines. Syntheses, Steroid Hormone Receptor Binding Affinities, and Cytostatic Activity

A number of acetoxy-substituted 5,6-dihydroindoloisoquinolines were synthesized and tested for binding affinity for steroid hormone receptors.All of the derivatives bind to the estrogen receptor with RBA values ranging from 1.5 to 17 (17β-estradiol