1233127-10-0Relevant articles and documents
Synthesis of Functionalized Furans via Chemoselective Reduction/Wittig Reaction Using Catalytic Triethylamine and Phosphine
Lee, Chia-Jui,Chang, Tzu-Hsiu,Yu, Jhen-Kuei,Madhusudhan Reddy, Ganapuram,Hsiao, Ming-Yu,Lin, Wenwei
, p. 3758 - 3761 (2016)
An efficient protocol for the synthesis of highly functionalized furans via intramolecular Wittig reaction has been developed using catalytic amounts of phosphine and triethylamine. Silyl chloride served as the initial promoter to activate the phosphine oxide. Reduction of the activated phosphine oxide by hydrosilane resulted in generation of phosphine, while decomposition of Et3N·HCl resulted in regeneration of base, which mediated formation of phosphorus ylide. Remarkably, the in situ generated byproduct, Et3N·HCl, also catalyzes reduction of phosphine oxide.
Preparation of tetrasubstituted furans via intramolecular wittig reactions with phosphorus ylides as intermediates
Kao, Tzu-Ting,Syu, Siang-En,Jhang, Yi-Wun,Lin, Wenwei
supporting information; experimental part, p. 3066 - 3069 (2010/08/19)
Novel preparation of tetrasubstituted furans, starting from the Michael acceptors, tributylphosphine, and acyl chlorides, is realized. A broad range of highly functional furans can be efficiently generated in one step at room temperature within 10 min to 21 h in moderate to high yields (60-99%). The reaction was proposed to proceed via intramolecular Wittig-type reactions, using phosphorus ylides as intermediates.