1233209-82-9

Upstream product

• 1233209-76-1 1β-(2-chloro-4-methylpyrimidin-5-yl)-1,2-dideoxy-3,5-di-O(t-butyldimethylsilyl)-D-ribofuranose 
• 98-80-6 phenylboronic acid 
• 181871-82-9 {(2R,3S)-3-[(tert-butyldimethylsilyl)oxy]-2,3-dihydrofuran-2-yl}methanol 
• 1233209-70-5 3′,5′-O-(tert-butyldimethylsilyl)-1β-[2,4-dichloropyrimidine-5-yl]-1,2-dideoxy-D-ribofuranose 
• 1233209-68-1 1β-(2,4-dichloropyrimidin-5-yl)-1,2-dideoxy-D-ribofuranose 
• 1233209-67-0 1β-(2,4-dichloropyrimidin-5-yl)-1,2,3-trideoxy-3-oxo-D-ribofuranose 
• 1233209-66-9 1β-(2,4-dichloropyrimidin-5-yl)-1,2-dideoxy-2,3-didehydro-3-O-(tert-butyldimethylsilyl)-D-ribofuranose 

Downstream Products

• 1233209-83-0 1β-(2-phenyl-4-methylpyrimidin-5-yl)-1,2-dideoxy-D-ribofuranose 

Relevant academic research and scientific papers

Synthesis of 2,4-disubstituted pyrimidin-5-yl C-2′- deoxyribonucleosides by sequential regioselective reactions of 2,4-dichloropyrimidine nucleosides

A new modular synthesis of diverse 2,4-disubstituted pyrimidin-5-yl C-2′-deoxyribonucleosides by sequential regioselective reactions of 2f6-dichloropyrimidm-5-yl C-nucleosides was developed. The intermediate was prepared by the Heck coupling of 2,6-dichloro-5-iodopyrimidine with glycal followed by desilylation and reduction. Its mild nucleophilic substitutions or Fe-catalyzed cross-coupling with MeMgCl proceeded regioselectively at position 4, whereas at elevated temperatures or with excess of MeMgCl, double substitution occurred. The 2-chloro-4-substituted intermediates undergo another substitution or coupling to afford 2,4-disubstituted derivatives.

A general regioselective approach to 2,4-disubstituted pyrimidin-5-yl C-2-deoxyribonucleosides

A new modular synthesis of diverse 2,4-disubstituted pyrimidin-5-yl C-2-deoxyribonucleosides by sequential regioselective reactions of 2,6-dichloropyrimidin-5-yl C-nucleoside was developed. The intermediate was prepared by the Heck coupling of 2,6-dichlor