1233249-57-4

Upstream product

• 37497-86-2 1-chloro-isoquinoline-4-carboxylic acid methyl ester 
• 55304-25-1 t-butyl 4-(cyanomethyl)benzoate 

Downstream Products

• 1233248-13-9 2-[1-[4-[2-(3,4-dichlorophenyl)ethylcarbamoyl]benzoyl]isoquinolin-4-yl]acetic acid 
• 1233248-16-2 2-[1-[4-[(4-chlorophenyl)carbamoyl]benzoyl]isoquinolin-4-yl]acetic acid 
• 1233248-11-7 2-[1-[4-[2-(4-chlorophenyl)ethylcarbamoyl]benzoyl]isoquinolin-4-yl]acetic acid 
• 1233249-62-1 methyl {1-[(4-{[2-(4-chlorophenyl)ethyl]carbamoyl}phenyl)carbonyl]isoquinolin-4-yl} acetate 
• 1233249-60-9 4-{[4-(2-methoxy-2-oxoethyl)isoquinolin-l-yl]carbonyl}benzoic acid 
• 1233248-12-8 2-[1-[4-[(3,4-dichlorophenyl)carbamoyl]benzoyl]isoquinolin-4-yl]acetic acid 
• 1233248-10-6 2-[1-[4-[(3,4-dichlorophenyl)methoxy]benzoyl]isoquinolin-4-yl]acetic acid 
• 1233249-59-6 tert-butyl 4-{[4-(2-methoxy-2-oxoethyl)isoquinolin-1-yl]carbonyl}benzoate 
• 1233249-54-1 methyl {1-[(4-methoxyphenyl)carbonyl]isoquinolin-4-yl} acetate 
• 1374249-87-2 C₂₆H₁₈Cl₂N₂O₄ 
• 1233249-61-0 C₂₀H₁₄ClNO₄ 
• 1233249-56-3 methyl [1-({4-[(3,4-dichlorabenzyl)oxy]phenyl}carbonyl)isoquinolin-4-yl]acetate 
• 1233249-55-2 methyl {1-[(4-hydroxyphenyl)carbonyl]isoquinolin-4-yl} acetate 
• 1233249-58-5 1-{[4-(tert-butoxycarbonyl)phenyl]carbonyl)isoquinoline-4-carboxylic acid 

Relevant academic research and scientific papers

Isoquinoline derivatives as potent CRTH2 receptor antagonists: Synthesis and SAR

Synthesis and structure-activity relationship of a novel series of isoquinoline CRTH2 receptor antagonists are described. One of the most potent compounds, TASP0376377 (6m), showed not only potent binding affinity (IC 50 = 19 nM) but also excellent functional antagonist activity (IC50 = 13 nM). TASP0376377 was tested for its ability of a chemotaxis assay to show the effectiveness (IC50 = 23 nM), which was in good agreement with the CRTH2 antagonist potency. Furthermore, TASP0376377 showed sufficient selectivity for binding to CRTH2 over the DP1 prostanoid receptor (IC50 >1 μM) and COX-1 and COX-2 enzymes (IC 50 >10 μM).

ISOQUINOLINE DERIVATIVE

A compound represented by formula (I) or a pharmaceutically acceptable salt thereof has an effect of inhibiting CRTH2 and, therefore, is useful as a preventive or a remedy for allergic diseases such as asthma, atopic dermatitis and allergic rhinitis.