1233249-54-1

Basic information

• Product Name: methyl {1-[(4-methoxyphenyl)carbonyl]isoquinolin-4-yl} acetate
• Synonyms: methyl {1-[(4-methoxyphenyl)carbonyl]isoquinolin-4-yl} acetate
• CAS NO: 1233249-54-1
• Molecular Weight: 335.359
• Mol File: 1233249-54-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl {1-[(4-methoxyphenyl)carbonyl]isoquinolin-4-yl} acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl {1-[(4-methoxyphenyl)carbonyl]isoquinolin-4-yl} acetate(1233249-54-1)
• EPA Substance Registry System: methyl {1-[(4-methoxyphenyl)carbonyl]isoquinolin-4-yl} acetate(1233249-54-1)

Safety Data

• Hazardous Substances Data: 1233249-54-1(Hazardous Substances Data)

Upstream product

• 1233249-53-0 1-[(4-methoxyphenyl)carbonyl]isoquinoline-4-carboxylic acid 
• 1233249-52-9 methyl 1-[(4-methoxyphenyl)carbonyl]isoquinoline-4-carboxylate 
• 104-47-2 p-methoxybenzylnitrile 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 37497-86-2 1-chloro-isoquinoline-4-carboxylic acid methyl ester 
• 55304-25-1 t-butyl 4-(cyanomethyl)benzoate 
• 1233249-58-5 1-{[4-(tert-butoxycarbonyl)phenyl]carbonyl)isoquinoline-4-carboxylic acid 
• 1233249-57-4 methyl 1-{[4-(tert-butoxycarbonyl)phenyl]carbonyl}isoquinoline-4-carboxylate 
• 67-56-1 methanol 

Downstream Products

• 1233248-10-6 2-[1-[4-[(3,4-dichlorophenyl)methoxy]benzoyl]isoquinolin-4-yl]acetic acid 
• 1233248-17-3 2-[1-[4-[2-(4-chlorophenyl)ethoxy]benzoyl]isoquinolin-4-yl]acetic acid 
• 1233248-18-4 2-[1-[4-[3-(4-chlorophenyl)propoxy]benzoyl]isoquinolin-4-yl]acetic acid 
• 1233249-63-2 methyl [1-({4-[2-(4-chlorophenyl)ethoxy]phenyl}carbonyl)isoquinolin-4-yl]acetate 
• 1233249-56-3 methyl [1-({4-[(3,4-dichlorabenzyl)oxy]phenyl}carbonyl)isoquinolin-4-yl]acetate 
• 1233249-55-2 methyl {1-[(4-hydroxyphenyl)carbonyl]isoquinolin-4-yl} acetate 

Relevant articles and documents

Isoquinoline derivatives as potent CRTH2 antagonists: Design, synthesis and SAR

In this study, we describe the synthesis and structure-activity relationship (SAR) of a series of isoquinoline chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonists. TASP0376377 (15-20), one of the most potent compounds, showed a potent binding affinity (IC50 = 19 nM) in addition to the excellent functional antagonist activity (IC50 = 13 nM). Moreover, the efficacy of this compound in a chemotaxis assay (IC50 = 23 nM) was in good agreement with its potency as a CRTH2 antagonist. In addition, 15-20 exhibited greater selectivity in binding to CRTH2 than to the DP1 prostanoid receptor (IC 50 >1 μM) or the enzymes COX-1 and COX-2 (IC50 >10 μM).

ISOQUINOLINE DERIVATIVE

A compound represented by formula (I) or a pharmaceutically acceptable salt thereof has an effect of inhibiting CRTH2 and, therefore, is useful as a preventive or a remedy for allergic diseases such as asthma, atopic dermatitis and allergic rhinitis.