1233355-08-2

Upstream product

• 1257313-53-3 C₁₄H₁₃BrFNO₃S 

Downstream Products

• 1233355-14-0 (S)-7-bromo-2-(4-fluorobenzyl)-3-phenyl-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazepine 1,1-dioxide 
• 1233355-13-9 (S)-7-bromo-2-(3,5-dimethoxybenzyl)-3-phenyl-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazepine 1,1-dioxide 
• 1233355-12-8 (S)-2-benzyl-7-bromo-3-phenyl-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazepine 1,1-dioxide 

Relevant academic research and scientific papers

Scaling out by microwave-assisted, continuous flow organic synthesis (MACOS): Multi-gram synthesis of bromo- and fluoro-benzofused Sultams Benzthiaoxazepine-1,1-dioxides

(Figure Presented). Go with the flow! Using a combination of continuous-flow techniques and microwave irradiation, a 19-member collection of 5-10 gram quantities of benzthiaoxazepine-1,1-dioxides has been produced (see scheme). The elimination of intermediate- and largescale process optimization by invoking the concept of scale-out (rather than scale up) has significantly reduced the time necessary to prepare these compounds.