1233518-05-2

Upstream product

• 150-13-0 4-amino-benzoic acid 
• 371958-90-6 4-(isobutylamino)benzoic acid 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 

Downstream Products

• 1233517-67-3 2-(4-(4-(4-(2-amino-N-benzylacetamido)-N-propylbenzamido)-N-isobutylbenzamido)benzamido)acetic acid 
• 1233517-58-2 2-(4-(4-(4-(benzylamino)-N-isobutylbenzamido)-N-isobutylbenzamido)benzamido)acetic acid 
• 1233517-59-3 2-(4-(4-(N-benzyl-4-(isobutylamino)benzamido)-N-isobutylbenzamido)benzamido)acetic acid 
• 1233517-60-6 N-(N-(N-(benzyl-4-aminobenzoyl)-N-benzyl-4-aminobenzoyl)-N-isobutyl-4-aminobenzoyl)glycine 
• 1233517-61-7 2-(4-(N-benzyl-4-(N-benzyl-4-(isobutylamino)benzamido)benzamido)benzamido)acetic acid 
• 1233517-62-8 2-(4-(N-benzyl-4-(N-isobutyl-4-(isobutylamino)benzamido)benzamido)benzamido)acetic acid 
• 1233517-63-9 2-(4-(N-benzyl-4-(4-(benzylamino)-N-isobutylbenzamido)benzamido)benzamido)acetic acid 
• 1233517-64-0 2-(4-(4-(4-(benzylamino)-N-(naphthalen-2-ylmethyl)benzamido)-N-isobutylbenzamido)benzamido)acetic acid 
• 1233517-57-1 2-(4-(N-isobutyl-4-(N-isobutyl-4-(isobutylamino)benzamido)benzamido)benzamido)acetic acid 
• 1233517-88-8 2-(4-(4-(4-(2-amino-N-benzylacetamido)-N-(naphthalen-2-ylmethyl)benzamido)-N-isobutylbenzamido)benzamido)acetic acid 
• 1233517-65-1 2-(4-(4-(4-(2-amino-N-(naphthalen-2-ylmethyl)acetamido)-N-(naphthalen-2-ylmethyl)benzamido)-N-isobutylbenzamido)benzamido)acetic acid 
• 1233517-66-2 2-(4-(4-(4-(2-amino-N-benzylacetamido)-N-isobutylbenzamido)-N-isobutylbenzamido)benzamido)acetic acid 
• 1444606-12-5 (S)-2-(4-(4-(4-(2-amino-N-isobutyl-3-methylbutanamido)-N-isobutylbenzamido)-N-isobutylbenzamido)benzamido)acetic acid 

Relevant academic research and scientific papers

Interfacing native and non-native peptides: using Affimers to recognise α-helix mimicking foldamers

Selection methods are used to identify Affimers that recognise α-helix mimicking N-alkylated aromatic oligoamides thus demonstrating foldamer and natural α-amino acid codes are compatible.

Microwave assisted solid phase synthesis of highly functionalized N-alkylated oligobenzamide α-helix mimetics

Protein-protein interactions (PPIs) mediate cellular pathways and are implicated in numerous aberrant conditions. α-Helix mimetics - small molecules that reproduce the spatial projection of key residues from an α-helix involved in a PPI - are attractive generic templates for development of screening libraries, however library syntheses of α-helix mimetics with diverse functionality are less established. This manuscript describes the automated, microwave assisted solid phase synthesis based on one such scaffold; an N-alkylated oligobenzamide.

N-alkylated oligoamide α-helical proteomimetics

Generic approaches for the design and synthesis of small molecule inhibitors of protein-protein interactions (PPIs) represent a key objective in modern chemical biology. Within this context, the α-helix mediated PPIs have received considerable attention as targets for inhibition using small molecules, foldamers and proteomimetics. This manuscript describes a novel N-alkylated aromatic oligoamide proteomimetic scaffold and its solid-phase synthesis - the first time such an approach has been used for proteomimetics. The utility of these scaffolds as proteomimetics is exemplified through the identification of potent μM inhibitors of the p53-hDM2 helix mediated PPI - a key oncogenic target.