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Usage

General Description

(S)-10-(2-nitrobenzoyl)-2,3-dihydro-1H-benzopyrrolo[1,2][1,4]diazepine-5,11(10H,11aH)-dione, also known as NBDP, is a compound with potential pharmacological effects. It is a benzodiazepine derivative with a nitrobenzoyl group attached to the 10th position. This chemical has been studied for its potential as an anti-cancer agent, as it has shown inhibitory effects on the growth of various cancer cell lines. Additionally, NBDP has also demonstrated potential as a DNA intercalating agent, which can affect gene transcription and expression. Further research is needed to fully understand the pharmacological properties and potential therapeutic applications of (S)-10-(2-nitrobenzoyl)-2,3-dihydro-1H-benzopyrrolo[1,2][1,4]diazepine-5,11(10H,11aH)-dione.

Upstream product

• 118-48-9 isatoic anhydride 
• 24919-40-2 (S)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H)-dione 
• 610-14-0 2-nitrobenzyl chloride 

Downstream Products

• 552-16-9 ortho-nitrobenzoic acid 
• 24919-40-2 (S)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H)-dione 

Relevant academic research and scientific papers

Low-valent titanium-mediated enantioselective synthesis of quinazolinone alkaloids circumdatins F, H, and analogs

We report the concise and protecting-group-free enantioselective total syntheses of circumdatins F and H. In view of the extreme importance of analogs of quinazolinone alkaloids in drug research and discovery, four analogs of bioactive quinazolinobenzodiazepine alkaloids, including demethoxycircumdatin H (12) and N-demethylbenzomalvin A (13), have been synthesized. The method is based on the low-valent titanium-promoted intramolecular reductive coupling of imides with o-nitrobenzimides, which yielded quinazolino[3,2-a][1,4]benzodiazepines under mild conditions. In addition, heptacyclic dehydraasperlicin E (16) has been synthesized from asperlicin C by a NCS-mediated dehydra-cyclization reaction.

A facile synthesis of quinazolino[1,4]benzodiazepine alkaloids via reductive N-heterocyclization of N-(2-nitrobenzoyl)amides: Total synthesis of asperlicin C, circumdatin H, and analogues

A facile and short synthesis of a series of quinazolino[1,4]benzodiazepine alkaloids, including asperlicin C, circumdatin H and some analogues, is reported utilizing coupling of readily available [1,4]benzodiazepine with 2-nitrobenzoyl chlorides, followed by a reductive N-heterocyclization. ARKAT USA, Inc.