1233707-35-1

Basic information

• Product Name: (R)-N-(1-(3-methoxyphenyl)ethyl)-P,P-diphenylphosphinic amide
• Synonyms: (R)-N-(1-(3-methoxyphenyl)ethyl)-P,P-diphenylphosphinic amide
• CAS NO: 1233707-35-1
• Molecular Weight: 351.385
• Mol File: 1233707-35-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (R)-N-(1-(3-methoxyphenyl)ethyl)-P,P-diphenylphosphinic amide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-(1-(3-methoxyphenyl)ethyl)-P,P-diphenylphosphinic amide(1233707-35-1)
• EPA Substance Registry System: (R)-N-(1-(3-methoxyphenyl)ethyl)-P,P-diphenylphosphinic amide(1233707-35-1)

Safety Data

• Hazardous Substances Data: 1233707-35-1(Hazardous Substances Data)

Upstream product

• 905458-53-9 P,P-diphenyl-N-[1-(3-methoxyphenyl)ethylidene]phosphinic amide 
• 122806-25-1 1-(3-methoxy-phenyl)-ethanone oxime 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 
• 544-97-8 dimethyl zinc(II) 
• 349451-05-4 N-(3-methoxybenzylidene)-P,P-diphenylphosphinic amide 
• 591-31-1 3-methoxy-benzaldehyde 
• 5994-87-6 diphenylphosphinamide 

Downstream Products

• 50919-07-8 (S)-1-(3-methoxyphenyl)ethylamine 
• 88196-70-7 (R)-1-(3-methoxyphenyl)ethylamine 
• 148717-49-1 tecalcet 
• 177172-48-4 (R)-3-(2-chlorophenyl)-N-(1-(3'-methoxyphenyl)ethyl)propanamide 

Relevant articles and documents

Asymmetric reduction method of nitrogen-phosphonyl protected imine

The invention discloses an asymmetric reduction method of nitrogen phosphonyl protective imine. The nitrogen phosphonyl protective imine is reduced into chiral amine in a hydrogen atmosphere under theaction of a metal catalyst and alkali, and the metal catalyst is prepared from a metal iridium complex and a nitrogen-phosphorus chiral ligand. The method provided by the invention has the characteristics of high enantioselectivity, high yield and high conversion number (TON). The method can be used for synthesizing various substituted chiral amines, can be used as an important intermediate for preparing various medicines, and has important significance for industrial production of medicines.

A dimethylzinc/diphenylphosphinoylimine approach to the asymmetric synthesis of the calcimimetic agent NPS R-568

An asymmetric synthesis of the calcimimetic agent NPS R-568 using a (1R,2S)-N-benzylephedrine-promoted addition of dimethylzinc to a diphenylphosphinoylimine derived from 3-methoxybenzaldehyde is described. The enantiomeric ratio of the key amine fragment was determined to be 93:7 (86% ee), favoring the (R)-enantiomer by derivatization and chiral stationary phase HPLC analysis.