148717-49-1

Basic information

• Product Name: TECALCET
• Synonyms: TECALCET
• CAS NO: 148717-49-1
• Molecular Formula: C18H22ClNO
• Molecular Weight: 303.831
• Mol File: 148717-49-1.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 416.3±40.0 °C(Predicted)
• Appearance: /
• Density: 1.092±0.06 g/cm3(Predicted)
• PKA: 9.41±0.29(Predicted)
• CAS DataBase Reference: TECALCET(CAS DataBase Reference)
• NIST Chemistry Reference: TECALCET(148717-49-1)
• EPA Substance Registry System: TECALCET(148717-49-1)

Safety Data

• Hazardous Substances Data: 148717-49-1(Hazardous Substances Data)

Upstream product

• 1006592-90-0 3-(2-chlorophenyl)-N-[(R)-1-(3-methoxyphenyl)ethyl]-2-propenamide 
• 1372628-56-2 3-((R)-1-((R)-1-phenylethylamino)ethyl)phenol 
• 1167414-89-2 (R)-1-(3-methoxyphenyl)ethanamine hydrochloride salt 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 
• 74738-21-9 3-(2'-chlorophenyl)-2-propenenitrile 
• 18655-48-6 3-(2-chlorophenyl)propan-1-amine 
• 89-98-5 2-chloro-benzaldehyde 
• 189289-49-4 [3-(2-Chloro-phenyl)-propyl]-[1-(3-methoxy-phenyl)-eth-(E)-ylidene]-amine 
• 266369-69-1 (R)-[1-(3-hydroxyphenyl)ethyl]carbamic acid tert-butyl ester 
• 871728-33-5 (R)-[1-(3-methoxyphenyl)ethyl]carbamic acid tert-butyl ester 
• 518060-42-9 (R)-1-(3-hydroxyphenyl)ethylamine 
• 120681-06-3 (E)-3-(2-chlorophenyl)acryloyl chloride 
• 121-71-1 3-Hydroxyacetophenone 
• 7315-17-5 3-(2-chloro-phenyl)-propionitrile 

Relevant articles and documents

Synthesis of NPS R-568 utilizing titanium-catalyzed asymmetric hydrosilylation

The enantioselective hydrosilylation of imines catalyzed by an (EBTHI) Ti (EBTHI=ethylene-bis(η5-tetrahydroindenyl) species was applied to the synthesis of NPS R-568, an active compound for the treatment of hyperparathyroidism.

Continuous-Flow Amide and Ester Reductions Using Neat Borane Dimethylsulfide Complex

Reductions of amides and esters are of critical importance in synthetic chemistry, and there are numerous protocols for executing these transformations employing traditional batch conditions. Notably, strategies based on flow chemistry, especially for amide reductions, are much less explored. Herein, a simple process was developed in which neat borane dimethylsulfide complex (BH3?DMS) was used to reduce various esters and amides under continuous-flow conditions. Taking advantage of the solvent-free nature of the commercially available borane reagent, high substrate concentrations were realized, allowing outstanding productivity and a significant reduction in E-factors. In addition, with carefully optimized short residence times, the corresponding alcohols and amines were obtained in high selectivity and high yields. The synthetic utility of the inexpensive and easily implemented flow protocol was further corroborated by multigram-scale syntheses of pharmaceutically relevant products. Owing to its beneficial features, including low solvent and reducing agent consumption, high selectivity, simplicity, and inherent scalability, the present process demonstrates fewer environmental concerns than most typical batch reductions using metal hydrides as reducing agents.

Sulfinamide Phosphinates as Chiral Catalysts for the Enantioselective Organocatalytic Reduction of Imines

A new type of chiral sulfinamide phosphinate catalysts with up to three stereogenic centers, readily accessible from commercially available starting materials, is reported. The naphthyl derivative SulPhos proved to be highly efficient in the organocatalyt