1233765-82-6

Upstream product

• 536-74-3 phenylacetylene 
• 99267-96-6 6-iodo-9-<2,3,5-tri-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl>purine 

Downstream Products

• 1233765-91-7 (Z)-6-(phenylethenyl)-9-(O,O,O-tris(tert-butyldimethylsilyl)-α-D-ribofuranosyl)-9H-purine 
• 646522-20-5 (E)-6-(phenylethenyl)-9-(O,O,O-tris(tert-butyldimethylsilyl)-α-D-ribofuranosyl)-9H-purine 

Relevant academic research and scientific papers

Synthesis of (E)-6-alkenylpurines via Pd-catalyzed stannation/ protodestannation tandem process of alkynylpurines

A methodology for the synthesis of (E)-6-alkenylpurines, starting from 6-iodopurines, based on a Pd-catalyzed stannation/protodestannation protocol, is described. The alkynylation reactions were catalyzed by Pd(OAc) 2/PPh3 in acetonitrile. The Pd-catalyzed stannation itself provided a mixture of Z regioisomers but following protodestannation using TFA induces Z to E isomerization giving (E)-6-alkenylpurines. The reactivity of other 2-and 8-alkynyl purines has also been studied.