1233765-91-7Relevant academic research and scientific papers
Synthesis of (E)-6-alkenylpurines via Pd-catalyzed stannation/ protodestannation tandem process of alkynylpurines
Klecka, Martin,KovacEK, Martin,Tobrman, Toma,Dvoak, Dalimil
experimental part, p. 313 - 332 (2010/08/05)
A methodology for the synthesis of (E)-6-alkenylpurines, starting from 6-iodopurines, based on a Pd-catalyzed stannation/protodestannation protocol, is described. The alkynylation reactions were catalyzed by Pd(OAc) 2/PPh3 in acetonitrile. The Pd-catalyzed stannation itself provided a mixture of Z regioisomers but following protodestannation using TFA induces Z to E isomerization giving (E)-6-alkenylpurines. The reactivity of other 2-and 8-alkynyl purines has also been studied.
