123392-44-9

Upstream product

• 67-56-1 methanol 
• 138485-81-1 3-(4-(methylmercapto)phenyl)propionic acid 
• 102016-58-0 p-(methylthio)cinnamic acid 
• 63545-55-1 [3-(4-mercaptoethyl)]propanoic acid 
• 74-88-4 methyl iodide 
• 3446-89-7 4-(Methylthio)benzaldehyde 

Downstream Products

• 1027730-11-5 methyl 3-[4-(methylsulfinyl)phenyl]propanoate 
• 737824-47-4 ethyl 4-[4-(methylthio)phenyl]-2-oxobutanoate 
• 116174-33-5 4-(4-methylsulfanyl-phenyl)butyric acid 
• 1057678-77-9 (4-(3-bromopropyl)phenyl)(methyl)sulfane 
• 59209-70-0 4-(methylthio)benzenepropanol 
• 737824-49-6 ethyl 2-amino-5-[4-(methylthio)benzyl]-1,3-thiazole-4-carboxylate 
• 737824-48-5 ethyl 3-bromo-4-[4-(methylthio)phenyl]-2-oxobutanoate 
• 737824-52-1 N-{5-[4-(methylthio)benzyl]-4-[2-(4-nitrophenyl)vinyl]-1,3-thiazol-2-yl}acetamide 
• 874900-00-2 C₁₄H₁₆N₂O₂S₂ 
• 737824-54-3 N-{4-[2-(4-{[amino(imino)methyl]amino}phenyl)ethyl]-5-[4-(methylsulfonyl)benzyl]-1,3-thiazol-2-yl}acetamide 
• 737824-92-9 N-{4-[2-(4-{[amino(imino)methyl]amino}phenyl)ethyl]-5-[4-(methylthio)benzyl]-1,3-thiazol-2-yl}acetamide 
• 737824-55-4 di-tert-butyl ((Z)-{[4-(2-{2-(acetylamino)-5-[4-(methylsulfonyl)benzyl]-1,3-thiazol-4-yl}ethyl)phenyl]amino}-methylidene)biscarbamate 
• 1429659-70-0 tert-butyl {(Z)-{[4-(2-{2-acetamido-5-[4-(methylsulfanyl)benzyl]-1,3-thiazol-4-yl}ethyl)phenyl]amino}-[(tert-butoxycarbonyl)amino]methylene}carbamate 
• 737824-46-3 N-{4-[2-(4-aminophenyl)ethyl]-5-[4-(methylsulfonyl)benzyl]-1,3-thiazol-2-yl}acetamide 

Relevant academic research and scientific papers

NOVEL PYRAZINE AMIDE COMPOUNDS

The present invention relates to compounds of formula 1 or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, R6 and X- have one of the meanings as indicated in the specification, to their use as a medicament, to their use in the treatment of a disease selected from among respiratory diseases or complaints and allergic diseases of the airways, to pharmaceutical composition comprising at least one of said compound or a pharmaceutically acceptable salt thereof, as well as to medicament combinations containing one or more of said compounds or a pharmaceutically acceptable salt thereof.

Synthesis and SAR study of new thiazole derivatives as vascular adhesion protein-1 (VAP-1) inhibitors for the treatment of diabetic macular edema: Part 2

Novel thiazole derivatives were synthesized and evaluated as vascular adhesion protein-1 (VAP-1) inhibitors. Although our previous compound 1 showed potent VAP-1 inhibitory activity, the activity differed between humans and rats. This issue was overcome by a hybrid design using human VAP-1 specific inhibitor 2, which was found by high-throughput screening (HTS), a docking study of a human VAP-1 homology model, and an analysis of sequence information for humans and rats. As a result, we identified compound 35c, which showed strong VAP-1 inhibitory activity (human IC50 of 20 nM; rat IC50 of 72 nM) and significant inhibitory effects in the ex vivo test.

SULFOXIMINES AS KINASE INHIBITORS

The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

THIAZOLE DERIVATIVES HAVING VAP-1 INHIBITORY ACTIVITY

A compound of the formula (I), (II), (III) or (IV): wherein each symbol is as defined in the specification,or a pharmaceutically acceptable salt thereof useful as a vascular adhesion protein-1 (VAP-1) inhibitor, a pharmaceutical composition, a method for preventing or treating a VAP-1 associated disease, especially macular edema, which method includes administering an effective amount of the compound or a pharmaceutically acceptable salt thereof to a subject, and the like.

THIAZOLE DERIVATIVES AND THEIR USE AS VAP-1 INHIBITORS

A compound of the formula (I): R1-NH-X-Y-Z (I) wherein R1 is acyl; X is a bivalent residue derived from optionally substituted thiazole; Y is a bond, lower alkylene or -COHN-; and Z is a groupe of the formulae (II) or (III) wherein R

Evaluation of the efficiency of the photocatalytic one-electron oxidation reaction of aromatic compounds adsorbed on a TiO2 surface

The TiO2 photocatalytic one-electron oxidation mechanism of aromatic sulfides with a methylene bridging group (-(CH2) n-, n = 0-4) between the 4-(methylthio)phenyl chromophore and the carboxylate binding group on the surfa