123392-71-2Relevant academic research and scientific papers
Scandium triflate-catalyzed intramolecular Friedel-Crafts acylation with Meldrum's acids: insight into the mechanism
Fillion, Eric,Fishlock, Dan
experimental part, p. 6682 - 6695 (2011/02/26)
The intramolecular Friedel-Crafts acylation of arenes with Meldrum's acid derivatives catalyzed by Sc(OTf)3 was reported as a mild and general entry into functionalized 1-indanones. Mechanistic investigations were undertaken to determine the rate-determining step in the acylation sequence using Meldrum's acid, as well as to examine the role of the Lewis acid catalyst. Enolizable Meldrum's acid derivatives react via an acyl ketene intermediate under thermal conditions, while quaternized Meldrum's acid derivatives are thermally stable and only act as effective Friedel-Crafts acylating agents in the presence of a Lewis acid catalyst. The acylation was postulated to proceed through direct acylation of a Lewis acid-activated carbonyl. In the catalytic Friedel-Crafts acylation of Meldrum's acids, triflic acid appeared to be the active catalytic species, with Sc(OTf)3 serving as a very mild and convenient reagent for its delivery.
A Facile Synthesis of α-Methyldesoxybenzoins Including Racemates of Natural Angolensin, 2-O-Methylangolensin and 4-O-Methylangolensin
Jain, A. C.,Paliwal, Poonam
, p. 985 - 988 (2007/10/02)
Methylation of four different 2-hydroxydesoxybenzoins ( 1a, 1c, 1d, 1f) separately with methyl iodide in the presence of dry potassium carbonate and acetone at 35-40 deg C affords both C-methyl-(2a, 2d) and O-methyl-(1b, 1e) derivatives.However, 1a provid
