24131-01-9Relevant academic research and scientific papers
Organocatalytic Enantioselective Decarboxylative Protonation Reaction of Meldrum's Acid Derivatives under PTC Conditions
Legros, Fabien,Martzel, Thomas,Brière, Jean-Fran?ois,Oudeyer, Sylvain,Levacher, Vincent
, p. 1975 - 1983 (2018/05/15)
An original organocatalyzed enantioselective protonation sequence of a transient quaternary ammonium enolate species has been developed by starting from readily available disubstituted Meldrum's acid derivatives and phenols. Under phase-transfer-catalytic (PTC) conditions, chiral nonracemic 2-aryl propionic ester derivatives were obtained in good isolated yields with enantioselectivities up to 70 % ee. The usefulness of the approach was demonstrated by the synthesis of enantioenriched (S)-ibuprofen.
Decarboxylative allylations of ester enolate equivalents
Ariyarathna, Yamuna,Tunge, Jon A.
supporting information, p. 8386 - 8389 (2014/12/10)
A variety of ester enolate equivalents are generated in situ and undergo α-allylation in high yields via palladium-catalyzed decarboxylative allylation. The transformations are complete within very short reaction times under ambient conditions. Synthesis of α-allylated acyl derivatives provides access to other carboxylic acid and alcohol derivatives via acyl group substitution or reduction. This journal is
Arylations mediated by lead(IV) in the presence of formazan and imine ligands
Iqbal, Amjid,Moloney, Mark G.,Siddiqui, Hamid Latif,Thompson, Amber L.
experimental part, p. 4523 - 4525 (2009/12/03)
The use of formazan and imine ligands in arylations of β-dicarbonyl systems by phenyl boronic acid/lead(IV) carboxylates is examined.
Synthesis of fused 4,5-disubstituted indole ring systems by intramolecular friedel-crafts acylation of 4-substituted indoles
Fillion, Eric,Dumas, Aaron M.
, p. 2920 - 2923 (2008/09/19)
(Chemical Equation Presented) 4-Substituted indoles containing a variety of electrophiles and N-substituents undergo Friedel-Crafts acylation to give exclusively the products of cyclization at the 5-position of indole. These indanones and tetralones have been scarcely prepared and are subunits in natural products and analogues of potential biological significance.
Ligand exchange and catalysis in phenylation reactions mediated by lead tetracarboxylates
Moloney, Mark G.,Paul, Diana R.,Thompson, Russell M.,Wright, Emma
, p. 77 - 88 (2007/10/03)
An investigation of catalysis and ligand exchange in the arylation of nucleophiles with phenylboronic acid and mixed ligand lead(IV) complexes is described. Although this reaction is known to be catalyzed by mercury(II) acetate, other heavy metals have be
The influence of ligands in Pinhey phenylation reactions using lead(IV) tetracarboxylates
Moloney, Mark G.,Paul, Diana R.,Prottey, Sophie C.,Thompson, Russell M.,Wright, Emma
, p. 195 - 205 (2007/10/03)
Lead(IV) tetracarboxylates, prepared from achiral and chiral carboxylic acids, have been shown to undergo metal-metal exchange with phenylboronic acid, and the phenyllead(IV) carboxylates thus generated in situ can be used for Pinhey phenylation reactions
