1233932-22-3

Basic information

• Product Name: 8-benzyl-6,6-difluoro-4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
• Synonyms: 8-benzyl-6,6-difluoro-4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
• CAS NO: 1233932-22-3
• Molecular Weight: 408.469
• Mol File: 1233932-22-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 8-benzyl-6,6-difluoro-4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane(CAS DataBase Reference)
• NIST Chemistry Reference: 8-benzyl-6,6-difluoro-4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane(1233932-22-3)
• EPA Substance Registry System: 8-benzyl-6,6-difluoro-4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane(1233932-22-3)

Safety Data

• Hazardous Substances Data: 1233932-22-3(Hazardous Substances Data)

Upstream product

• 23583-21-3 ethyl-3-benzylamino propionate 
• 98-09-9 benzenesulfonyl chloride 
• 1067914-81-1 3,3-difluoro-1-(phenylmethyl)-4,4-piperidinediol 
• 851314-55-1 ethyl N-[3-(ethyloxy)-2,2-difluoro-3-oxopropyl]-N-(phenylmethyl)-beta-alaninate 
• 851314-56-2 ethyl 5,5-difluoro-4-hydroxy-1-(phenylmethyl)-1,2,5,6-tetrahydro-3-pyridinecarboxylate 
• 851314-54-0 ethyl N-(1H-1,2,3-benzotriazol-1-ylmethyl)-N-(phenylmethyl)-beta-alaninate 

Downstream Products

• 1233932-23-4 6,6-difluoro-4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane 
• 1233929-29-7 6,6-difluoro-N-phenyl-4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane-8-carboxamide 

Relevant articles and documents

Discovery of spiropiperidine-based potent and selective Orexin-2 receptor antagonists

To generate novel human Orexin-2 Receptor (OX2R) antagonists, a spiropiperidine based scaffold was designed and a SAR study was carried out. Compound 4f possessed the highest OX2R antagonistic activity with an IC 50 value of 3 nM with 450-fold selectivity against Orexin-1 Receptor (OX1R).