1233946-39-8

Basic information

• Product Name: 3′,5′-di-O-acetyl-N⁶-phenoxycarbonyl-2′-deoxyadenosine
• Synonyms: 3′,5′-di-O-acetyl-N⁶-phenoxycarbonyl-2′-deoxyadenosine
• CAS NO: 1233946-39-8
• Molecular Weight: 455.427
• Mol File: 1233946-39-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3′,5′-di-O-acetyl-N⁶-phenoxycarbonyl-2′-deoxyadenosine(CAS DataBase Reference)
• NIST Chemistry Reference: 3′,5′-di-O-acetyl-N⁶-phenoxycarbonyl-2′-deoxyadenosine(1233946-39-8)
• EPA Substance Registry System: 3′,5′-di-O-acetyl-N⁶-phenoxycarbonyl-2′-deoxyadenosine(1233946-39-8)

Safety Data

• Hazardous Substances Data: 1233946-39-8(Hazardous Substances Data)

Upstream product

• 958-09-8 2'-deoxy-D-adenosine 
• 17318-24-0 3',5'-di-O-acetyl-2'-deoxyadenosine 
• 64897-46-7 1-N-methyl-3-phenoxycarbonylimidazolium chloride 

Downstream Products

• 1233946-47-8 3',5'-di-O-acetyl-N₆-{2-[N₁-(4-methoxytrityl)-imidazol-4-yl]ethylaminocarbonyl}-2'-deoxyadenosine 
• 1233946-55-8 5'-O-(4,4'-dimethoxytrityl)-N₆-[(1S,2R)-1-{[2-(trimethylsilyl)ethoxy]-carbonyl}-2-{[(tert-butyl)dimethylsilyl]oxy}propylaminocarbonyl]-2'-deoxyadenosine 
• 1233946-59-2 3'-O-(2-cyanoethyl-N,N-diisopropylaminophosphinoxy)-5'-O-(4,4'-dimethoxytrityl)-N₆-[(1S,2R)-1-{[2-(trimethylsilyl)ethoxy]carbonyl}-2-{[(tert-butyl)dimethylsilyl]oxy}propylaminocarbonyl]-2'-deoxyadenosine 

Relevant articles and documents

DNA binding and cleavage studies of copper(II) complexes with 2′-deoxyadenosine modified histidine moiety

This work is focused on the study of DNA binding and cleavage properties of 2′-deoxyadenosines modified with ester/amide of histidine (his6dA ester, his6dA amide) and their copper(II) complexes. To determine the coordination mode of

RNA-cleaving 10-23 deoxyribozyme with a single amino acid-like functionality operates without metal ion cofactors

A series of 10-23 deoxyribozymes (D2-D9) containing single amino-acid-bearing nucleosides (thr6dA, hisam6dA, hisam5dU and ncmnm5dU) at positions 4, 5, 8 or 15 of the catalytic core was obtained by chemical synthesis. The deoxyribozymes were screened for their catalytic efficiency, and in the presence of 1 mM Mg 2+ two of them, containing at position 8 either hisam5dU (D8) or ncmnm5dU (D9), were found to be RNA nucleases several times more active than their non-modified precursor. Moreover, in the magnesium-free TRIS or PIPES buffers, these enzymes were able to catalyze the cleavage of the phosphodiester bond located between the 5'-GpU-3' sequence of the complementary RNA substrate. The cleavage reaction proceeded with the highest efficiency at pH > 7.