1233946-55-8

Basic information

• Product Name: 5'-O-(4,4'-dimethoxytrityl)-N₆-[(1S,2R)-1-{[2-(trimethylsilyl)ethoxy]-carbonyl}-2-{[(tert-butyl)dimethylsilyl]oxy}propylaminocarbonyl]-2'-deoxyadenosine
• Synonyms: 5'-O-(4,4'-dimethoxytrityl)-N₆-[(1S,2R)-1-{[2-(trimethylsilyl)ethoxy]-carbonyl}-2-{[(tert-butyl)dimethylsilyl]oxy}propylaminocarbonyl]-2'-deoxyadenosine
• CAS NO: 1233946-55-8
• Molecular Weight: 913.231
• Mol File: 1233946-55-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5'-O-(4,4'-dimethoxytrityl)-N₆-[(1S,2R)-1-{[2-(trimethylsilyl)ethoxy]-carbonyl}-2-{[(tert-butyl)dimethylsilyl]oxy}propylaminocarbonyl]-2'-deoxyadenosine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-(4,4'-dimethoxytrityl)-N₆-[(1S,2R)-1-{[2-(trimethylsilyl)ethoxy]-carbonyl}-2-{[(tert-butyl)dimethylsilyl]oxy}propylaminocarbonyl]-2'-deoxyadenosine(1233946-55-8)
• EPA Substance Registry System: 5'-O-(4,4'-dimethoxytrityl)-N₆-[(1S,2R)-1-{[2-(trimethylsilyl)ethoxy]-carbonyl}-2-{[(tert-butyl)dimethylsilyl]oxy}propylaminocarbonyl]-2'-deoxyadenosine(1233946-55-8)

Safety Data

• Hazardous Substances Data: 1233946-55-8(Hazardous Substances Data)

Upstream product

• 958-09-8 2'-deoxy-D-adenosine 
• 17318-24-0 3',5'-di-O-acetyl-2'-deoxyadenosine 
• 1233946-43-4 3',5'-di-O-acetyl-N₆-[(1S,2R)-1-{[2-(trimethylsilyl)ethoxy]carbonyl}-2-{[(tert-butyl)dimethylsilyl]oxy}propylaminocarbonyl]-2'-deoxyadenosine 
• 1233946-39-8 3′,5′-di-O-acetyl-N⁶-phenoxycarbonyl-2′-deoxyadenosine 
• 1233946-45-6 N₆-[(1S,2R)-1-{[2-(trimethylsilyl)ethoxy]carbonyl}-2-{[(tert-butyl)dimethylsilyl]oxy}propylaminocarbonyl]-2'-deoxyadenosine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 

Downstream Products

• 1233946-59-2 3'-O-(2-cyanoethyl-N,N-diisopropylaminophosphinoxy)-5'-O-(4,4'-dimethoxytrityl)-N₆-[(1S,2R)-1-{[2-(trimethylsilyl)ethoxy]carbonyl}-2-{[(tert-butyl)dimethylsilyl]oxy}propylaminocarbonyl]-2'-deoxyadenosine 

Relevant articles and documents

RNA-cleaving 10-23 deoxyribozyme with a single amino acid-like functionality operates without metal ion cofactors

A series of 10-23 deoxyribozymes (D2-D9) containing single amino-acid-bearing nucleosides (thr6dA, hisam6dA, hisam5dU and ncmnm5dU) at positions 4, 5, 8 or 15 of the catalytic core was obtained by chemical synthesis. The deoxyribozymes were screened for their catalytic efficiency, and in the presence of 1 mM Mg 2+ two of them, containing at position 8 either hisam5dU (D8) or ncmnm5dU (D9), were found to be RNA nucleases several times more active than their non-modified precursor. Moreover, in the magnesium-free TRIS or PIPES buffers, these enzymes were able to catalyze the cleavage of the phosphodiester bond located between the 5'-GpU-3' sequence of the complementary RNA substrate. The cleavage reaction proceeded with the highest efficiency at pH > 7.