1234-17-9

Basic information

• Product Name: 1-[4-(dimethylamino)phenyl]-3-(4-nitrophenyl)prop-2-en-1-one
• CAS NO: 1234-17-9
• Molecular Formula: C₁₇H₁₆N₂O₃
• Molecular Weight: 296.3205
• Mol File: 1234-17-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 466.4°C at 760 mmHg
• Flash Point: 235.9°C
• Density: 1.236g/cm³
• Vapor Pressure: 7.09E-09mmHg at 25°C
• Refractive Index: 1.655
• CAS DataBase Reference: 1-[4-(dimethylamino)phenyl]-3-(4-nitrophenyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(dimethylamino)phenyl]-3-(4-nitrophenyl)prop-2-en-1-one(1234-17-9)
• EPA Substance Registry System: 1-[4-(dimethylamino)phenyl]-3-(4-nitrophenyl)prop-2-en-1-one(1234-17-9)

Safety Data

• Hazardous Substances Data: 1234-17-9(Hazardous Substances Data)

Usage

Physical state

Yellow solid

Usage

Organic synthesis and building block for pharmaceuticals and organic compounds

Optical property

Exhibits yellow fluorescence under UV light

Potential applications

Optoelectronic materials

Medicinal properties

Anti-inflammatory and antioxidant activities

Researched for

Treatment of various diseases and conditions

Versatility

Potential applications in various industries and scientific fields

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 2124-31-4 4'-dimethylaminoacetophenone 

Downstream Products

• 78807-72-4 2-[5-(4-Dimethylamino-phenyl)-3-(4-nitro-phenyl)-4,5-dihydro-pyrazol-1-yl]-1-phenothiazin-10-yl-ethanone 

Relevant articles and documents

A chalcone-based fluorescent responsive probe for selective detection of nitroreductase activity in bacteria

A new chalcone-based fluorescent turn-on probe (3c) responsive to nitroreductase (NTR) activity and its application toward the detection of bacteria are presented. The probe exhibits turn-on fluorescence at 535 nm in response to NTR activity and its optic

Biologically active 1,3-bis-aromatic-prop-2-en-1-ones, 1,3-bis-aromatic-propan-1-ones, and 1,3-bis-aromatic-prop-2-yn-1-ones

The invention relates to the use of 1,3-bis-aromatic-prop-2-en-1-ones (chalcones), 1,3-bis-aromatic-propan-1-ones (dihydrochalcones), and 1,3-bis-aromatic-prop-2-yn-1-ones for the preparation of pharmaceutical compositions for the treatment or prophylaxis of a number of serious diseases including i) conditions relating to harmful effects of inflammatory cytokines, ii) conditions involving infection by Helicobacter species, iii) conditions involving infection by viruses, iv) neoplastic disorders, and v) conditions caused by microorganisms or parasites. The invention also relates to novel chalcones and dihydrochalcones (especially alkoxy substituted variants) having advantageous substitution patterns with respect to their effect as drug substances, and to methods of preparing them, as well as to pharmaceutical compositions comprising the novel chalcones. Moreover, the present invention relates to a method for the isolation of Leishmania fumarate reductase, QSAR methodologies for selecting potent compounds for the above-mentioned purposes.

Synthesis and Biological Activity of Some New 10-phenothiazines

Fourteen 10-phenothiazines (IV) have been synthesized via condensation of 10-hydrazino-acetylphenothiazine with substituted benzalacetophenones.These compounds inhibit 33-86percent in vitro activity of rat brain pyruvate oxidase and afford protection against pentylenetetrazol induced seizures in albino mice.However, their anticonvulsant properties are found to be independent of their pyruvate oxidase inhibitory activity.