1234-28-2

Basic information

• Product Name: 1,3-bis(4-nitrophenyl)thiourea
• Synonyms: thiourea, N,N'-bis(4-nitrophenyl)-
• CAS NO: 1234-28-2
• Molecular Formula: C₁₃H₁₀N₄O₄S
• Molecular Weight: 318.3079
• Mol File: 1234-28-2.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 503.5°C at 760 mmHg
• Flash Point: 258.3°C
• Density: 1.58g/cm³
• Vapor Pressure: 2.89E-10mmHg at 25°C
• Refractive Index: 1.791
• CAS DataBase Reference: 1,3-bis(4-nitrophenyl)thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-bis(4-nitrophenyl)thiourea(1234-28-2)
• EPA Substance Registry System: 1,3-bis(4-nitrophenyl)thiourea(1234-28-2)

Safety Data

• Hazardous Substances Data: 1234-28-2(Hazardous Substances Data)

Usage

Physical state

Yellow to orange crystalline solid

Solubility

Insoluble in water, soluble in organic solvents

Primary use

Reagent for the determination of heavy metals in various substances

Reaction with metal ions

Forms insoluble complexes

Additional uses

Synthesis of other organic compounds, photometric reagent for the determination of nitro compounds

Toxicity

Toxic if ingested or inhaled

Hazards

Can cause skin and eye irritation

Safety precautions

Handle with caution

Upstream product

• 463-71-8 thiophosgene 
• 100-01-6 4-nitro-aniline 
• 2131-61-5 p-nitrophenyl isothiocyanate 
• 17356-08-0 thiourea 
• 103-72-0 phenyl isothiocyanate 
• 75-15-0 carbon disulfide 

Downstream Products

• 587-90-6 bis-N,N'-(4-nitrophenyl)urea 
• 18440-30-7 N,N',N''-tris-(4-nitro-phenyl)-guanidine 
• 51964-21-7 3-(4-nitro-phenyl)-2-(4-nitro-phenylimino)-thiazolidin-4-one 
• 65672-99-3 (4-nitro-phenyl)-[3-(4-nitro-phenyl)-[1,3]thiazetidin-2-ylidene]-amine 
• 61333-96-8 5-methyl-3-(4-nitro-phenyl)-2-(4-nitro-phenylimino)-thiazolidin-4-one 
• 82686-76-8 [4-Isopropyl-3-(4-nitro-phenyl)-3H-thiazol-(2Z)-ylidene]-(4-nitro-phenyl)-amine 
• 82844-54-0 5,5-Bis-(2-hydroxy-phenyl)-1,3-bis-(4-nitro-phenyl)-2-thioxo-imidazolidin-4-one 
• 82694-19-7 [5-Ethyl-4-methyl-3-(4-nitro-phenyl)-3H-thiazol-(2Z)-ylidene]-(4-nitro-phenyl)-amine 
• 82686-60-0 [5-Isopropyl-4-methyl-3-(4-nitro-phenyl)-3H-thiazol-(2Z)-ylidene]-(4-nitro-phenyl)-amine 
• 82694-35-7 [4-Ethyl-5-methyl-3-(4-nitro-phenyl)-3H-thiazol-(2Z)-ylidene]-(4-nitro-phenyl)-amine 
• 859187-78-3 N,N'-bis-(4-nitro-phenyl)-N''-phenyl-guanidine 
• 26946-76-9 (6-nitro-benzothiazol-2-yl)-(4-nitro-phenyl)-amine 
• 13806-75-2 N-(4-nitrophenyl)thiocarbamic acid O-ethyl ester 
• 79051-54-0 2-(p-nitrophenylimino)-3-(p-nitrophenyl)-4-(m-nitrophenyl)-Δ4-thiazoline 

Relevant articles and documents

Electron density distribution studies as a tool to explore the behaviour of thiourea-based anion receptors

Building on previous studies of anion-receptor complexes based on a urea scaffold substituted symmetrically with electron-withdrawing nitro groups, the electron density distribution in an analogous thiourea receptor complex and the related asymmetrically

A thiourea-based chromoionophore for selective binding and sensing of acetate

Highly selective binding and sensing of acetate over various monovalent inorganic anions (MeCO2-?H2PO4- >Cl-, Br-, I-, SCN-, NO3-, HSO

Hydrogen-Bond Catalysis of Imine Exchange in Dynamic Covalent Systems

The reversibility of imine bonds has been exploited to great effect in the field of dynamic covalent chemistry, with applications such as preparation of functional systems, dynamic materials, molecular machines, and covalent organic frameworks. However, acid catalysis is commonly needed for efficient equilibration of imine mixtures. Herein, it is demonstrated that hydrogen bond donors such as thioureas and squaramides can catalyze the equilibration of dynamic imine systems under unprecedentedly mild conditions. Catalysis occurs in a range of solvents and in the presence of many sensitive additives, showing moderate to good rate accelerations for both imine metathesis and transimination with amines, hydrazines, and hydroxylamines. Furthermore, the catalyst proved simple to immobilize, introducing both reusability and extended control of the equilibration process.

A simple and straightforward synthesis of phenyl isothiocyanates, symmetrical and unsymmetrical thioureas under ball milling

Promoted by KOH under ball milling, anilines were efficiently transformed into isothiocyanates (in presence of 5.0 equiv. CS2) or symmetrical thioureas (in presence of 1.0 equiv. CS2), without using any other harsh or toxic decomposition reagent. Some in situ generated isothiocyanates can directly "click" with other amines to afford unsymmetrical thioureas.