1234064-19-7

Basic information

• Product Name: Mini₁₀₆
• CAS NO: 1234064-19-7
• Molecular Weight: 427.352
• Mol File: 1234064-19-7.mol

Chemical Properties

• CAS DataBase Reference: Mini₁₀₆(CAS DataBase Reference)
• NIST Chemistry Reference: Mini₁₀₆(1234064-19-7)
• EPA Substance Registry System: Mini₁₀₆(1234064-19-7)

Safety Data

• Hazardous Substances Data: 1234064-19-7(Hazardous Substances Data)

Upstream product

• 1242272-87-2 C₁₃H₁₁FO₂ 
• 76-05-1 trifluoroacetic acid 
• 164223-35-2 ethyl 5-{[(benzyloxy)carbonyl]amino}-3-oxopentanoate 

Relevant articles and documents

Development of pH-responsive fluorescent false neurotransmitters

We introduce pH-responsive fluorescent false neurotransmitters (pH-responsive FFNs) as novel probes that act as vesicular monoamine transporter (VMAT) substrates and ratiometric fluorescent pH sensors. The development of these agents was achieved by systematic molecular design that integrated several structural elements, including the aminoethyl group (VMAT recognition), halogenated hydroxy-coumarin core (ratiometric optical pH sensing in the desired pH range), and N- or C-alkylation (modulation of lipophilicity). Of 14 compounds that were synthesized, the probe Mini202 was selected based on the highest uptake in VMAT2-transfected HEK cells and desirable optical properties. Using Mini202, we measured the pH of catecholamine secretory vesicles in PC-12 cells (pH -5.9) via two-photon fluorescence microscopy. Incubation with methamphetamine led to an increase in vesicular pH (pH - 6.4), consistent with a proposed mechanism of action of this psychostimulant, and eventually to redistribution of vesicular content (including Mini202) from vesicles to cytoplasm. Mini202 is sufficiently bright, photostable, and suitable for two-photon microscopy. This probe will enable fundamental neuroscience and neuroendocrine research as well as drug screening efforts.

pH-responsive fluorescent false neurotransmitters and their use

This invention relates to compounds having the following structure: wherein Y is O, X is O, bond α is absent and bond β is present, or Y is H, X is CH, bond α is present, and bond β is absent; atom Z is a carbon and bonds χ, δ and γ are present, or atom Z is a nitrogen and bonds χ, δ and γ are absent, or atom Z is a nitrogen and bonds χ and δ are present and γ is absent. R1, R2, R3, R4, R5, and R6 are various substituents as described in the specification.

PH RESPONSIVE FLUORESCENT FALSE NEUROTRANSMITTERS AND THEIR USE

This invention relates to compounds having the following structure: wherein Y is O, X is O, bond α is absent and bond β is present, or Y is H, X is CH, bond α is present, and bond β is absent; atom Z is a carbon and bonds χ, δ and γ are present, or atom Z is a nitrogen and bonds χ, δ and γ are absent, or atom Z is a nitrogen and bonds χ and δ are present and γ is absent. R1, R2, R3, R4, R5, and R6 are various substituents as described in the specification.