123418-69-9

Usage

Uses

Used in Pharmaceutical Industry:
5-Bromo-4-chlorothiophene-2-carboxylic acid serves as an intermediate in the synthesis of various pharmaceuticals. Its unique structure and functional groups contribute to the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
5-broMo-4-chlorothiophene-2-carboxylic acid is also utilized as an intermediate in the production of agrochemicals, which are essential for enhancing crop protection and improving agricultural yields.
Used in Organic Compounds and Materials Production:
5-Bromo-4-chlorothiophene-2-carboxylic acid is employed in the synthesis of a range of organic compounds and materials, showcasing its versatility in different chemical applications and industries.

Upstream product

• 59614-95-8 4-Chloro-2-thiophenecarboxylic Acid 
• 57681-59-1 1-(4,5-Dichlor-2-thienyl)-ethanon 
• 88-15-3 2-Acetylthiophene 
• 123418-66-6 1-(5-bromo-4-chlorothiophen-2-yl)ethan-1-one 
• 34730-20-6 1-(4-chlorothiophen-2-yl)ethan-1-one 

Relevant academic research and scientific papers

PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS

This disclosure generally relates to pyridine-2-one compounds of formula (I) and methods of using them in the treatment of a disorder, such as cancer or a SMARCA2-associated disorder, including as antagonists (e.g., inhibitors) of SMARCA2. The present disclosure provides treatment modalities, e.g., strategies, treatment methods, patient stratification methods, compounds, combinations, and compositions that are useful for the treatment of disorders, e.g., proliferative disorders, such as certain cancers. Some aspects of this disclosure provide treatment modalities, methods, strategies, compounds, compositions, combinations, and dosage forms for the treatment of cell proliferative disorders, e.g., cancers with decreased activity or function, or loss of function, of SMARCA4 with a SMARCA2 antagonist.

THIOPHENE, MANUFACTURING METHOD THEREOF, AND PHARMACEUTICAL APPLICATION OF SAME

The present invention discloses a thiophene used as a uric acid transporter (URAT1) inhibitor and applicantion of the thiophene in preparing a pharmaceutical product for treating a disease related to abnormal uric acid levels, specifically in preparing a pharmaceutical product for treating hyperuricemia and gouty arthritis. The invention specifically relates to a compound as represented by formula (I) or a pharmaceutically acceptable salt thereof.

NAMPT inhibitors

Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.

INHIBITORS OF Akt ACTIVITY

Invented are novel thiophene compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.

Herbicidal Thienylureas, I

Syntheses of the title substances as potential herbicides are described by a modified Curtius degradation of corresponding thiophene carboxylic acids, obtained in turn by haloform reaction of appropriate acetyl thiophenes.Regioselective substitution reactions of thiophenes were key steps for the construction of desired substitution patterns.Structure-activity considerations show that especially the 3-thienyl ureas 36 and 38 exhibit significant herbicidal activity comparable with commercial products. - Keywords: Curtius degradation; Herbicides; Thiophenes; Ureas; Urethanes