123433-62-5Relevant academic research and scientific papers
Substituted Pyrrolidines and Methods of Use
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Paragraph 2059, (2018/04/20)
The invention discloses compounds of Formula (I) wherein R1, R2, R2A, R3, R3A, R4, R4A, and R5 are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.
SYSTHESIS AND INTRAMOLECULAR RING CLEAVAGE OF 2-OXETANONES
Mead, Keith T.,Samuel, Beverly
, p. 6573 - 6576 (2007/10/02)
Intermolecular 2+2 aldehyde-ketene cycloaddition, followed by Lewis acid induced intramolecular ring opening of the 2-oxetanone product have been used to prepare tetrahydrofuran and tetrahydropyran ring systems.
