1234340-41-0Relevant academic research and scientific papers
Catalytic Friedel–Crafts Reactions of Highly Electronically Deactivated Benzylic Alcohols
Vukovi?, Vuk D.,Richmond, Edward,Wolf, Eléna,Moran, Joseph
, p. 3085 - 3089 (2017)
Highly electronically deactivated benzylic alcohols, including those with a CF3 group adjacent to the OH-bearing carbon, undergo dehydrative Friedel–Crafts reactions upon exposure to catalytic Br?nsted acid in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) solvent. Titration and kinetic experiments support the involvement of higher order solvent/acid clusters in catalysis.
Direct Pd-catalyzed benzylation of highly electron-deficient perfluoroarenes
Fan, Shilu,He, Chun-Yang,Zhang, Xingang
supporting information; experimental part, p. 4926 - 4928 (2010/07/16)
An efficient and practical method to a wide range of perfluorinated unsymmetrical diarylmethanes with good to excellent yields and high regioselectivities has been developed by Pd-catalyzed direct benzylation of highly electron-deficient perfluoroarenes; excellent compatibility of functional groups has also been established.
