123439-71-4Relevant academic research and scientific papers
Synthesis of 4-Substituted 2-Aminopyrrolopyrimidine 2',3'-Dideoxyribonucleosides
Seela, Frank,Muth, Heinz-Peter
, p. 227 - 232 (2007/10/02)
A number of new 2-aminopyrrolopyrimidine N-7-(2',3'-dideoxyribonucleosides) (11 - 13 and 15) were synthesized.These are related to 7-deaza-2',3'-dideoxyguanosine (14), but carry various substituents at C-4. 2-Amino-4-chloro-7-(2',3'-dideoxy-β-D-glycero-pentofuranosyl)-7H-pyrrolopyrimidine (3) was used as a common intermediate, and was obtained from the corrsponding 2'-deoxyribonucleoside 4 by selective silylation of 5'-OH and Barton deoxygenation of 3'-OH.
