123458-49-1Relevant academic research and scientific papers
Synthesis of New Heterocyclic Phenols: 9-Hydroxypyridopyrimidin-4-one and Derivatives
Dennin, F.,Blondeau, D.,Sliwa, H.
, p. 1287 - 1291 (2007/10/02)
9-Hydroxypyridopyrimidin-4-one (5) was prepared by condensation of 2-amino-3-hydroxypyridine with isopropylidene aminomethylenemalonate.The reaction first led to an enaminoester intermediate which underwent cyclization by heating at 250 deg C affording the new heterocyclic phenol 5.A similar condensation performed on 2-amino-3-benzyloxypyridine yielded the corresponding benzylic ether which can be easily debenzylated to 5 by hydrogenolysis.Furthermore 2-amino-3-benzyloxypyridine condensed with diethyl ethoxymethylenemalonate gave 9-benzyloxy-3-ethoxycarbonylpyridopyrimidin-4-one which was also debenzylated to the corresponding free phenol.
SYNTHESIS OF NEW HETEROCYCLIC PHENOLS : 9-HYDROXY-PYRIDO PYRIMIDINE-4-ONE AND 9-HYDROXY-PYRIMIDOPYRIMIDINE-4-ONE
Dennin, F.,Blondeau, D.,Sliwa, H.
, p. 1529 - 1530 (2007/10/02)
The novel title phenols have been prepared by condensation of a derivative of Meldrum acid with 3-benzyloxy-2-amino-pyridine or 5-benzyloxy-4-amino-pyrimidine, and subsequent hydrogenolysis of the protecting group.
