137557-18-7

Basic information

• Product Name: Isopropylidene N-(3-hydroxy-2-pyridyl)aminomethylenemalonate
• Synonyms: Isopropylidene N-(3-hydroxy-2-pyridyl)aminomethylenemalonate
• CAS NO: 137557-18-7
• Molecular Formula: C12H12N2O5
• Molecular Weight: 264
• Mol File: 137557-18-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Isopropylidene N-(3-hydroxy-2-pyridyl)aminomethylenemalonate(CAS DataBase Reference)
• NIST Chemistry Reference: Isopropylidene N-(3-hydroxy-2-pyridyl)aminomethylenemalonate(137557-18-7)
• EPA Substance Registry System: Isopropylidene N-(3-hydroxy-2-pyridyl)aminomethylenemalonate(137557-18-7)

Safety Data

• Hazardous Substances Data: 137557-18-7(Hazardous Substances Data)

Upstream product

• 16867-03-1 2-amino-3-hydroxypyridine 
• 15568-85-1 5-methoxymethylene-2,2-dimethyl-1,3-dioxane-4,6-dione 

Downstream Products

• 123458-49-1 9-hydroxy-pyrido <1,2-a> pyrimidine-4-one 

Relevant articles and documents

Synthesis of New Heterocyclic Phenols: 9-Hydroxypyridopyrimidin-4-one and Derivatives

9-Hydroxypyridopyrimidin-4-one (5) was prepared by condensation of 2-amino-3-hydroxypyridine with isopropylidene aminomethylenemalonate.The reaction first led to an enaminoester intermediate which underwent cyclization by heating at 250 deg C affording the new heterocyclic phenol 5.A similar condensation performed on 2-amino-3-benzyloxypyridine yielded the corresponding benzylic ether which can be easily debenzylated to 5 by hydrogenolysis.Furthermore 2-amino-3-benzyloxypyridine condensed with diethyl ethoxymethylenemalonate gave 9-benzyloxy-3-ethoxycarbonylpyridopyrimidin-4-one which was also debenzylated to the corresponding free phenol.