123458-61-7

Basic information

• Product Name: Δ2-Cefuroxime Axetil
• Synonyms: Δ2-Cefuroxime Axetil;(6R,7R)-3-[[(AMinocarbonyl)oxy]Methyl]-7-[[(2Z)-2-(2-furanyl)-2-(MethoxyiMino)acetyl]aMino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic Acid 1-(Acetyloxy)ethyl Ester;[6R-[6α, 7β(Z)]]-3-[[(Aminocarbonyl)oxy]methyl]-7-[[2-furanyl(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid 1-(acetyloxy)ethyl ester;Cefuroxime Axetil EP Impurity A;Cefuroxime Axetil Impurity A (EP);Cefuroxime Axetil Impurities (EP)
• CAS NO: 123458-61-7
• Molecular Formula: C20H22N4O10S
• Molecular Weight: 510.47448
• Product Categories: Chiral Reagents;Drug Analogues;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Chiral Reagents, Drug Analogues, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
• Mol File: 123458-61-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.61±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 8.33±0.60(Predicted)
• CAS DataBase Reference: Δ2-Cefuroxime Axetil(CAS DataBase Reference)
• NIST Chemistry Reference: Δ2-Cefuroxime Axetil(123458-61-7)
• EPA Substance Registry System: Δ2-Cefuroxime Axetil(123458-61-7)

Safety Data

• Hazardous Substances Data: 123458-61-7(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 123458-61-7 differently. You can refer to the following data:
1. It is an oral prodrug of Cefuroxime (C248060), an injectable second generation cephalosporin with an excellent antibacterial activity. This ester is applied in therapy as a mixture of the R and S diastereoisomers.
2. Δ2-Cefuroxime Axetil (Cefuroxime Axetil EP Impurity A) is an oral prodrug of Cefuroxime (C248060), an injectable second generation cephalosporin with an excellent antibacterial activity. This ester is applied in therapy as a mixture of the R and S diastereoisomers.

Upstream product

• 64544-07-6 cefuroxime axetil 

Relevant articles and documents

Cefuroxime axetil-3-ene isomer preparation method

The invention relates to a cefuroxime axetil-3-ene isomer preparation method, and belongs to medicine quality research, quality control and safety research of pharmaceutical enterprises. The steps comprise: (1) in an aprotic solvent and a protic solution, generating a 3-ene isomeric cefuroxime axetil and cefuroxime axetil mixture from cefuroxime axetil under the catalytic action of an alkali; and(2) purifying the 3-ene isomeric cefuroxime axetil and cefuroxime axetil mixture obtained in the step (1) through reversed-phase C18 column preparative liquid chromatography, extracting, drying, andconcentrating to obtain the cefuroxime axetil-3-ene isomer, wherein the chromatographic conditions of purifying comprise that a ratio of water to methanol is 40/60, the flow rate is 40 ml/min, and theultraviolet detection wavelength is 23 nm. According to the invention, the method has advantages of simple reaction operation, mild conditions and high product purity, and the obtained cefuroxime axetil-3-ene isomer can be used as a standard substance in quality control of cefuroxime axetil bulk drugs and preparations.