64544-07-6Relevant articles and documents
A process for the preparation of cefuroxime axetil (by machine translation)
-
Paragraph 0055-0058, (2016/10/10)
The invention discloses a preparation method of cefuroxime axetil. The method comprises the following steps: completely dissolving cefuroxime acid in dimethylformamide, and carrying out esterification reaction with 1-bromethylacetate under the catalytic action of cupric chloride; and hydrolyzing with ethyl acetate and sodium chloride solution, extracting, carrying out vacuum distillation, crystallizing with cyclohexane, carrying out vacuum filtration, and drying to obtain high-purity cefuroxime axetil. The cupric chloride, which has the advantages of no toxicity, no harm and high catalytic efficiency, is preferably used as the catalyst; the cyclohexane for crystallization is easy to recover and reutilize, thereby lowering the production cost; and meanwhile, the method has the advantages of mild and controllable reaction conditions, short production cycle and lower energy consumption, and is suitable for industrial production.
Cephalosporin antibiotics
-
, (2008/06/13)
The invention provides novel antibiotic cefuroxime esters of the formula STR1 (wherein R1 is a primary or secondary alkyl group containing 1 to 4 carbon atoms and R2 is a primary or secondary alkyl group containing 1 to 6 carbon atoms provided that at least one of the groups R1 and R2 is methyl). These compounds are useful as orally administrable broad spectrum antibiotics.
Process for the preparation of cephalosporin compounds
-
, (2008/06/13)
A process for the preparation of cephalosporins having a phosphonocarbamoyloxymethyl group at the 3-position by reacting a cephalosporin having at the 3-position a group STR1 (wherein R4 and R5 are independently alkyl, aralkyl, alicyclic or aryl groups or together form a divalent group) with a compound of formula STR2 (wherein R6, R7 and R8 are independently alkyl, aralkyl, alicyclic or aryl groups or any two of R6, R7 and R8 together form a divalent group, and X is halogen) followed by hydrolysis. The 3-phosphonocarbamoyloxymethyl cephalosporin products of the process exhibit antibiotic activity, and if desired may be readily converted to 3-carbamoyloxymethyl cephalosporins which themselves show antibiotic activity.
