1234616-25-1

Usage

Uses

Used in Organic Synthesis:
4-Bromo-1-methyl-1H-pyrrolo[2,3-b]pyridine is utilized as a key intermediate in organic synthesis for creating a range of heterocyclic compounds. Its unique structure allows for the formation of new chemical entities with potential applications in various fields.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 4-Bromo-1-methyl-1H-pyrrolo[2,3-b]pyridine is employed as a precursor for the development of pharmaceuticals. Its ability to be incorporated into the molecular structures of drugs makes it instrumental in the discovery and design of new therapeutic agents.
Used in the Preparation of Regioselectively Functionalized Pyrrolo[2,3-b]pyridine Derivatives:
4-Bromo-1-methyl-1H-pyrrolo[2,3-b]pyridine is also used as a precursor for the preparation of regioselectively functionalized pyrrolo[2,3-b]pyridine derivatives. These derivatives are of interest due to their potential biological activities and may be further optimized for specific therapeutic targets.
Used in Pharmaceutical Development:
4-Bromo-1-methyl-1H-pyrrolo[2,3-b]pyridine is used as a building block in the pharmaceutical industry for the synthesis of biologically active compounds. Its incorporation into drug molecules can lead to the discovery of new drugs with improved efficacy and selectivity.

Upstream product

• 74-88-4 methyl iodide 
• 348640-06-2 4-bromo-7-azaindole 

Downstream Products

• 1644629-23-1 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine 
• 1422965-54-5 4-(4-methoxyphenoxy)-1-methyl-1H-pyrrolo[2,3-b]pyridine 
• 1422965-53-4 1-methyl-4-(m-tolyloxy)-1H-pyrrolo[2,3-b]pyridine 
• 1422965-36-3 N-(1-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)benzene sulfonamide 
• 1422965-35-2 N-(1-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide 

Relevant academic research and scientific papers

HPK1 ANTAGONISTS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

Diversification of Heteroaryl-Aryl Ether via Ligand-Free, Copper-Catalyzed O-Arylation Under Microwave Heating

Diverse O-arylated pyrrolo[2,3-d]pyrimidine and pyrrolo[2,3-b]pyridine were obtained using relatively low amounts of Cu catalyst with ligand-free conditions under microwave heating. The O-arylation reaction could be applied to less oxidative heteroaryl-chlorides. The microwave-assisted Cu-catalyzed O-aryaltion would be useful for preparing potent bioactive compounds for drug discovery while reducing waste, time, and saving energy.

ARYL-BIPYRIDINE AMINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS

The invention relates to inhibitors of PI5P4K inhibitors useful in the treatment of cancers, neurodegenerative diseases, inflammatory disorders, and metabolic diseases, having the Formula (I): wherein A, X, Y, Z, Q, R1, R2, R3, R4, R5, and n are described herein.

Palladium-catalyzed aminocarbonylation of halo-substituted 7-azaindoles and other heteroarenes using chloroform as a carbon monoxide source

A palladium-catalyzed aminocarbonylation of halo-substituted 7-azaindoles utilizing CHCl3 as the carbonyl source has been developed for the straightforward incorporation of an amide functional group. The protocol was extended to other heteroarenes such as pyrazolopyridines and indazoles. The substrate scope of the reaction with respect to heteroarenes and the amine component is reported. This method offers an alternative avenue for aminocarbonylation of pharmaceutically important heterocycles.

Discovery and optimization of 2-(4-substituted-pyrrolo[2,3-b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR)

We discovered 2-(4-substituted-pyrrolo[2,3-b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR). Since phenolic OH groups pose metabolic liability, one of th