1234618-22-4Relevant academic research and scientific papers
Cobalt-Catalyzed Regio- A nd Enantioselective Allylic Alkylation of Malononitriles
Ghorai, Samir,Ur Rehman, Sajid,Xu, Wen-Bin,Huang, Wen-Yu,Li, Changkun
, p. 3519 - 3523 (2020)
Cobalt-catalyzed highly branched- A nd enantioselective allylic alkylation of malononitriles has been developed. Chiral ?,?′-unsaturated malononitriles could be synthesized with >20:1 branched/linear regioselectivity and up to 99% enantiomeric excess from easily accessible racemic allylic carbonates under mild reaction conditions. The electron-rich and sterically less hindered bisoxazolinephosphine ligand is essential to realize the high reactivity in the carbon-carbon bond formation process.
Iridium-catalyzed kinetic asymmetric transformations of racemic allylic benzoates
Stanley, Levi M.,Bai, Chen,Ueda, Mitsuhiro,Hartwig, John F.
supporting information; experimental part, p. 8918 - 8920 (2010/08/21)
Versatile methods for iridium-catalyzed, kinetic asymmetric substitution of racemic, branched allylic esters are reported. These reactions occur with a variety of aliphatic, aryl, and heteroaryl allylic benzoates to form the corresponding allylic substitution products in high yields (74-96%) with good to excellent enantioselectivity (84-98% ee) with a scope that encompasses a range of anionic carbon and heteroatom nucleophiles. These kinetic asymmetric processes occur with distinct stereochemical courses for racemic aliphatic and aromatic allylic benzoates, and the high reactivity of branched allylic benzoates enables enantioselective allylic substitutions that are slow or poorly selective with linear allylic electrophiles.
