1234679-83-4Relevant academic research and scientific papers
Synthesis and NLO properties of new trans 2-(thiophen-2-yl)vinyl heteroaromatic iodides
Fortuna, Cosimo Gianluca,Bonaccorso, Carmela,Qamar, Fadi,Anu, Anu,Ledoux, Isabelle,Musumarra, Giuseppe
experimental part, p. 1608 - 1613 (2011/04/18)
The synthesis and characterisation of new trans 2-(thiophen-2-yl)vinyl pyridinium, imidazolium and quinoilinium iodides is reported together with their solvatochromic shifts and EFISH characterization. 2-{(E)-2-[5′- (dibutylamino)-2,2′-bithien-5-yl]vinyl}
Design, synthesis and biological evaluation of trans 2-(thiophen-2-yl)vinyl heteroaromatic iodides
Fortuna, Cosimo G.,Barresi, Vincenza,Musumarra, Giuseppe
experimental part, p. 4516 - 4523 (2010/08/22)
A modeling approach based on physico-chemical and pharmacokinetic properties, called Volsurf+, was used to design new trans 2-(thiophen-2-yl)vinyl heteroaromatic iodides with antiproliferative activity. The synthesis and in vitro antitumor tests on two cell lines (MCF-7 and LNCap) confirmed Volsurf predicted activity values. An Almond model, derived to have an overall structural insight on the above compounds, supported the validity of Volsurf and provided guidelines for the synthesis of new compounds.
