876-87-9

Usage

InChI:InChI=1/C11H13N/c1-9-7-8-10-5-3-4-6-11(10)12(9)2/h3-9H,1-2H3

Upstream product

• 91-63-4 2-methylquinoline 
• 98-95-3 nitrobenzene 
• 74-88-4 methyl iodide 
• 16021-55-9 1,2-dimethyl-1,2-dihydroquinoline 
• 3947-76-0 N-methylquinolinium iodide 
• 62-53-3 aniline 

Downstream Products

• 2412-10-4 N,N-dimethylmorpholinium iodide 
• 40123-69-1 N-(1'-Methylquinolyl-2'-methyl)pyridinium-diiodid 
• 32901-40-9 5-methyl-4-[(1-methyl-1H-[2]quinolyliden)-ethylidene]-2-phenyl-2,4-dihydro-pyrazol-3-one 
• 23978-38-3 4-[2-(1-methyl-1H-quinolin-2-ylidene)-ethylidene]-2-phenyl-4H-oxazol-5-one 
• 68704-07-4 4-[4-(1-methyl-1H-[2]chinolyLiDene)-but-2-enylidene]-2-phenyl-4H-oxazol-5-one 
• 104644-94-2 1-methyl-2-(3-nitro-2-phenyl-propyl)-quinolinium; iodide 
• 110605-32-8 2-(3-dimethylamino-trans-styryl)-1-methyl-quinolinium; iodide 
• 7469-64-9 2-(3,4-diethoxy-trans-styryl)-1-methyl-quinolinium; iodide 
• 79377-13-2 N-[2-(1-methyl-1H-[2]quinolyliden)-ethylidene]-p-phenetidine; hydriodide 
• 32901-40-9 5-methyl-4-[2-(1-methyl-1H-quinolin-2-ylidene)-ethylidene]-2-phenyl-2,4-dihydro-pyrazol-3-one 
• 3859-97-0 (E)-2-(4-fluorostyryl)-1-methylquinolin-1-ium iodide 
• 5418-78-0 1-methyl-2-(3-nitro-trans-styryl)-quinolinium; iodide 

Relevant academic research and scientific papers

Dynamically Monitoring Cell Viability in a Dual-Color Mode: Construction of an Aggregation/Monomer-Based Probe Capable of Reversible Mitochondria-Nucleus Migration

Mitochondria and nucleus play crucial roles during cell apoptosis process. In this work, a unique fluorescent probe capable of reversible migration between mitochondria and nucleus, as well as detection of cell viability in a dual-color mode is presented. The dual-color probe targets mitochondria in healthy cells, to form aggregates with deep-red emission. It migrates into nucleus and binds to DNA to form monomers with green fluorescence during apoptosis. Interestingly, the migration is reversible dependent on cell viability, which enables the dynamic visualization of apoptosis process. With the probe, mitochondria and nucleus can be visualized in dual colors during apoptosis, and the cell viability could be monitored by the emission color and localization of the probe.

A new coumarin-based “turn-on” fluorescence probe with high sensitivity and specificity for detecting hypochlorite ion

A new type of “turn-on” fluorescence probe coumarin-based DTC was developed for specifically detecting hypochlorite ion (ClO?) with high sensitivity. DTC can display a significant enhancement of fluorescence and emit blue fluorescence at 452 nm after reaction with ClO?. Moreover, probe DTC can detect ClO? without interference from other reactive oxygen species (ROS), and has a low detection limit for ClO? of 96 nM. Meanwhile, DTC can also detect ClO? in the physiological environment, and DTC can be further used as a test paper-strip for portable and rapid detection of ClO?.

Design and Synthesis of Novel c-di-GMP G-Quadruplex Inducers as Bacterial Biofilm Inhibitors

The formation of biofilms by clinical pathogens typically leads to chronic and recurring antibiotic-resistant infections. High cellular levels of cyclic diguanylate (c-di-GMP), a ubiquitous secondary messenger of bacteria, have been proven to be associate

Fluorescent probe for detecting mitochondrial membrane potentials, and preparation method and application thereof

The invention belongs to the technical field of analytical chemistry, and provides a fluorescent probe for detecting mitochondrial membrane potentials as well as a preparation method and application thereof. The fluorescent probe for detecting the mitocho

An Activatable and Switchable Nanoaggregate Probe for Detecting H2S and Its Application in Mice Brains

Employing a sequentially activated probe design method, an activatable, switchable and dual-mode probe was designed. This nanoprobe, HSDPP, could be effectively activated by H2S to form H-type aggregates with green emission; subsequently, the aggregates could bind to mtDNA to form monomers and the emIssion color switched from green to deep-red. We exploited HSDPP to image exogenous and endogenous H2S in living cells. Of note, for the first time, this novel nanoprobe with an optimal partition coefficient value (LogP=1.269) was successfully applied for tracking the endogenous H2S upregulation stimulated by cystathionase activator S-adenosyl-L-methionine (SAM) in mice brains. Finally, our work provides an invaluable chemical tool for probing endogenous H2S upregulation in vitro/vivo and, importantly, affords a prospective design strategy for developing switchable chemosensors to unveil the relationship between biomolecules and DNA in mitochondria in many promising areas.

Phenothiazine dye for detecting hypochlorite ions as well as preparation method and application thereof

The invention discloses a phenothiazine dye for detecting hypochlorite ions as well as a preparation method and application thereof. The preparation method comprises the following steps: dissolving phenothiazine and bromo-ethane in a solvent, adding sodium hydroxide, purifying to obtain 10-ethyl-10H-phenothiazine; dropwise adding phosphorus oxychloride into N,N-dimethyl formamide, carrying out reactions at a low-temperature, adding 10-ethyl-10H-phenothiazine, carrying out a reaction to obtain 10-ethyl-10H-phenothiazine-3-formaldehyde, dissolving 3-methylquinoline and methyl iodide into anhydrous toluene, adding acetone, carrying out purification to obtain 1,2-dimethylquinoline-1-iodide; dissolving 10-ethyl-10H-phenothiazine-3-formaldehyde and 1,2-dimethylquinoline-1-iodide, dropwise addingpiperidine, and purifying to obtain a target product. The fluorescent probe only has fluorescence response to hypochlorite, and has the characteristics of good water solubility, high selectivity, high response speed, low detection cost and high sensitivity.

Carbazole-based fluorescent probes for G-quadruplex DNA targeting with superior selectivity and low cytotoxicity

G-quadruplex DNA plays a very important role in clinical diagnosis and fluorescence analysis has attracted extensive attention. A class of carbazole-based fluorescent probes for the detection of G-quadruplex DNA was established in this work. In this system, the installation of an oligo(ethylene glycol) chain on the scaffold will improve the water-solubility and biocompatibility. The presence of styrene-like different side groups could tune the selectivity toward G-quadruplex DNA binding. Results revealed that the substitution pattern and position gave a great influence on the ability for the discrimination of the G-quadruplex from other DNA structures. Especially, probe E1 bound to G-quadruplex DNA with superior selectivity, which exhibiting almost no fluorescence response in the presence of non-G-quadruplex DNA structures. Comprehensive analyses revealed that E1 could bind both ends of the G-quadruplex, resulting in a significant increase of fluorescence emission intensity. Cellular uptake assay suggested that E1 could pass through membrane and enter living cells with low cytotoxicity.

Multiple-Color Platinum Complex with Super-Large Stokes Shift for Super-Resolution Imaging of Autolysosome Escape

It is of great significance to track the platinum drugs in real time with super-resolution to elucidate their mechanism of action, such as their behavior and distribution in live cells. Such information is required for further drug development. However, i

A highly sensitive ratiometric fluorescent probe for imaging endogenous hydrogen sulfide in cells

Hydrogen sulfide has been shown to play important regulatory roles in more and more physiological and pathological processes. Therefore, it is necessary to develop highly sensitive, selective and reliable probes for detecting hydrogen sulfide to reveal its specific role in the progression of certain diseases. Here, a novel ratiometric fluorescent probe for imaging hydrogen sulfide was designed by connecting the azide group with the N-methylquinoline quaternary ammonium salt through a styrene group. This probe has high selectivity and good sensitivity, and can image the changes of endogenous hydrogen sulfide in living cells. This journal is

Fluorescent probe for mitochondrial membrane potential as well as synthesis method and application thereof

The invention provides a fluorescent probe for mitochondrial membrane potential as well as a synthesis method and application thereof. The structural formula of the probe is as shown in the followingdescriptions. The probe can be synthesized with a reaction product 6-hexyloxyl-2-naphthaldehyde of 6-hydroxyl-2-naphthaldehyde and hexane iodide and a reaction product 1,2-dimethyl-quinoline iodate of2-methylquinoline and methyl iodide. The probe provided by the invention can be used for distinguishing different membrane potential. The fluorescent probe provided by the invention is large in fluorescent wavelength displacement when responding to the mitochondrial membrane potential and low in toxicity to a cell; and the fluorescent probe is simple in synthesis method and simple and convenientin purification step. The probe is successfully applied to cell imaging, and can be used for distinguishing the change of the mitochondrial membrane potential.