123470-47-3

Basic information

• Product Name: 2H-Benzimidazole-2-thione,5,6-difluoro-1,3-dihydro-(9CI)
• Synonyms: 2H-Benzimidazole-2-thione,5,6-difluoro-1,3-dihydro-(9CI);5,6-DIFLUORO-1H-BENZIMIDAZOLE-2-THIOL;5,6-Difluoro-1H-benzoimidazole-2-thiol
• CAS NO: 123470-47-3
• Molecular Formula: C₇H₄F₂N₂S
• Molecular Weight: 186.18
• Product Categories: BENZIMIDAZOLE
• Mol File: 123470-47-3.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2H-Benzimidazole-2-thione,5,6-difluoro-1,3-dihydro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Benzimidazole-2-thione,5,6-difluoro-1,3-dihydro-(9CI)(123470-47-3)
• EPA Substance Registry System: 2H-Benzimidazole-2-thione,5,6-difluoro-1,3-dihydro-(9CI)(123470-47-3)

Safety Data

• Hazardous Substances Data: 123470-47-3(Hazardous Substances Data)

Usage

Structure

Heterocyclic compound with a benzimidazole ring, two fluorine atoms, and a thione functional group

Use

Primarily used in the pharmaceutical industry for its potential antimicrobial and antifungal properties

Applications

Potential in the development of new drugs and agrochemicals

Bioactivity

The presence of fluorine atoms may contribute to its bioactivity and stability

Potential

Valuable building block for the synthesis of novel compounds with potential therapeutic uses

Research

Further research and development needed to fully understand its potential biological activities and applications

Upstream product

• 75-15-0 carbon disulfide 
• 76179-40-3 2-amino-4,5-difluoroaniline 
• 1662-21-1 N-(3,4-difluoro-2-nitrophenyl)acetamide 
• 458-11-7 3,4-difluoroacetanilide 
• 78056-39-0 4,5-difluoro-2-nitroaniline 
• 140-89-6 potassium ethyl xanthogenate 

Downstream Products

• 352216-39-8 2-(5,6-difluoro-1H-benzoimidazol-2-ylsulfanyl)-1-(2,4-dimethoxy-phenyl)-ethanone 
• 372187-95-6 1-(2,4-dichloro-phenyl)-2-(5,6-difluoro-1H-benzoimidazol-2-ylsulfanyl)-ethanone 
• 175727-16-9 5,6-difluoro-2-benzimidazolylhydrazine 
• 372188-01-7 2-(1-acetyl-5,6-difluoro-1H-benzoimidazol-2-ylsulfanyl)-1-(2,4-dimethoxy-phenyl)-ethanone 
• 372188-00-6 2-(1-acetyl-5,6-difluoro-1H-benzoimidazol-2-ylsulfanyl)-1-(2,4-dichloro-phenyl)-ethanone 
• 372187-98-9 2-(1-acetyl-5,6-difluoro-1H-benzoimidazol-2-ylsulfanyl)-1-(4-bromo-phenyl)-ethanone 
• 372187-99-0 2-(1-acetyl-5,6-difluoro-1H-benzoimidazol-2-ylsulfanyl)-1-(4-chloro-phenyl)-ethanone 

Relevant articles and documents

2-SUBSTITUTED PROLINE BIS-AMIDE OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to 2-substituted proline bis-amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

2,4-Bis (trifluoroethoxy)pyridine compound and drug containing the compound

The present invention is directed to a 2,4-bis(trifluoroethoxy)pyridine compound represented by formula (1): (wherein X1 represents a fluorine atom or a hydrogen atom) or a salt thereof, and to a drug containing the compound or the salt as an active ingredient. The compound has metabolic resistance in human liver microsome, good absorbability upon oral administration, and excellent ACAT inhibitory activity.

Human chymase inhibitors

The present invention provides a benzimidazole derivative or its. pharmaceutically permissible salt expressed by the following formula (1). Further, the present invention provides a human chymase activity inhibitor containing the substance as an active ingredient. (the ring marked with A expresses a pyridline ring or a benzene ring; X1 and X2 are each a hydrogen atom, a halogen atom, a trihalomethyl group, a cyano group, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, or the like; B is a substituted or unsubstituted alkylene group, or the like; E is -COOR4 or the like; G is a substituted or unsubstituted alkylene group; J is a substituted or unsubstituted alkyl group, or a substituted or unsubstituted aryl group; and M is a sulfur atom, sulfoxidde, sulfone or the like).