123477-29-2

Upstream product

• 123477-28-1 (3S,5R)-3,5-Dihydroxy-6-trityloxy-hexanoic acid tert-butyl ester 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 123477-28-1 (3R,5R)-3,5-Dihydroxy-6-trityloxy-hexanoic acid tert-butyl ester 
• 123477-28-1 1,1-Dimethylethyl (3R,5S)-3,5-dihydroxy-6-(triphenylmethoxy)hexanoate 
• 150942-98-6 t-butyl lithioacetate 
• 288-32-4 1H-imidazole 
• 113240-61-2 1,1-Dimethylethyl (S)-5-hydroxy-3-oxo-6-(triphenylmethoxy)hexanoate 
• 144754-24-5 (S)-methyl 3-hydroxy-4-(trityloxy)butanoate 
• 113240-61-2 (R)-5-Hydroxy-3-oxo-6-trityloxy-hexanoic acid tert-butyl ester 
• 144754-24-5 methyl (R)-3-hydroxy-4-(triphenylmethyl)oxybutanoate 

Downstream Products

• 123492-49-9 (3S,5R)-3,5-Bis-(tert-butyl-diphenyl-silanyloxy)-6-hydroxy-hexanoic acid tert-butyl ester 
• 123492-49-9 (3R,5R)-3,5-Bis-(tert-butyl-diphenyl-silanyloxy)-6-hydroxy-hexanoic acid tert-butyl ester 
• 123492-49-9 1,1-Dimethylethyl (3R,5S)-3,5-di[(1-,1-dimethylethyl)diphenylsilyloxy]-6-hydroxyhexanoate 
• 123477-30-5 1,1-Dimethylethyl (3R,5S)-3,5-di-[(1',1'-dimethylethyl)-diphenylsilyloxy]-6-oxohexanoate 
• 130852-64-1 (3R,5R)-3,5-Bis-(tert-butyl-diphenyl-silanyloxy)-6-oxo-hexanoic acid tert-butyl ester 
• 116168-28-6 (3S,5R)-3,5-Bis-(tert-butyl-diphenyl-silanyloxy)-6-oxo-hexanoic acid tert-butyl ester 

Relevant academic research and scientific papers

A Highly Stereoselective Route to the Four Stereoisomers of a Six-Carbon Synthon

The syntheses of chiral synthones 13-16 are described utilizing the chiral pool approach starting from either S- or R-malic acid.

Imidazole analogs of mevalonolactone and derivatives thereof for use in inhibiting cholesterol biosynthesis and lowering blood cholesterol level

Compounds of the formula STR1 and the pharmaceutically acceptable acid addition salts thereof, wherein the various substituents are defined hereinbelow and the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.

Pyrazolopyridine analogs of mevalonolactone and derivatives thereof useful for inhibiting cholesterol biosynthesis in mammals

Compounds of the formula STR1 and processes for and intermediates in the synthesis thereof, pharmaceutical compositions comprising such a compound and the use of such compounds for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis.