1234798-38-9

Basic information

• Product Name: N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-phenyl)-4-methyl-3-(4-pyridin-3-yl-thiazol-2-ylamino)-benzamide
• Synonyms: N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-phenyl)-4-methyl-3-(4-pyridin-3-yl-thiazol-2-ylamino)-benzamide
• CAS NO: 1234798-38-9
• Molecular Weight: 534.565
• Mol File: 1234798-38-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-phenyl)-4-methyl-3-(4-pyridin-3-yl-thiazol-2-ylamino)-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-phenyl)-4-methyl-3-(4-pyridin-3-yl-thiazol-2-ylamino)-benzamide(1234798-38-9)
• EPA Substance Registry System: N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-phenyl)-4-methyl-3-(4-pyridin-3-yl-thiazol-2-ylamino)-benzamide(1234798-38-9)

Safety Data

• Hazardous Substances Data: 1234798-38-9(Hazardous Substances Data)

Upstream product

• 641571-11-1 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline 
• 1186620-63-2 methyl 4-methyl-3-(4-(pyridin-3-yl)thiazol-2-ylamino)benzoate 
• 6221-12-1 3-Bromoacetylpyridine 
• 1234798-76-5 3-(3-acetylthiourea)-4-methylbenzoic acid methyl ester 
• 18595-18-1 3-amino-4-methyl benzoic acid methyl ester 
• 54962-75-3 [3-bromo-5-(trifluoromethyl)phenyl]amine 

Relevant articles and documents

Hybrid compounds as new Bcr/Abl inhibitors

A series of 2,4-disubstituted thiazole derivatives were designed and synthesized as new Bcr/Abl inhibitors by hybriding the structural moieties from FDA approved imatinib, nilotinib and dasatinib. The new inhibitors strongly suppressed the activity of Bcr/Abl kinase and potently inhibited the proliferation of K562 and KU812 leukemia cancer cells. Compound 4i displayed comparable potency with that of nilotinib in both biochemical kinase assay and cancer cell growth inhibition assay. These inhibitors might serve as lead compounds for further developing new anticancer drugs.