1234862-83-9

Upstream product

• 591-50-4 iodobenzene 
• 53081-61-1 (E)-1-(but-1-en-3-yn-1-yl)-4-chlorobenzene 
• 873-73-4 4-n-chlorophenylacetylene 
• 98-86-2 acetophenone 
• 1620635-60-0 (E)-1-chloro-4-(4,4-dibromobuta-1,3-dienyl)benzene 
• 1075-77-0 (E)-4-chlorocinnamic aldehyde 
• 42205-91-4 (2-(4-chlorophenyl)cyclopropyl)(phenyl)methanone 

Relevant academic research and scientific papers

Regio- and Stereoselective Cascade of β,γ-Unsaturated Ketones by Dipeptided Phosphonium Salt Catalysis: Stereospecific Construction of Dihydrofuro-Fused [2,3-b] Skeletons

Chiral (dihydro)furo-fused heterocycles are significant structural motifs in numerous natural products, functional materials and pharmaceuticals. Therefore, developing efficient methods for preparing compounds with these privileged scaffolds is an important endeavor in synthetic chemistry. Herein, we develop an effective, modular method by a dipeptide-phosphonium salt-catalyzed regio- and stereoselective cascade reaction of readily available linear β,γ-unsaturated ketones with aromatic alkenes, affording a wide variety of structurally fused heterocyclic molecules in high yields with excellent stereoselectivities. Moreover, mechanistic investigations revealed that the bifunctional phosphonium salt controlled the regio- and stereoselectivities of this cascade reaction, particularly proceeding through the initial ketone α-addition followed by O-participated substitution; and the multiple hydrogen-bonding interactions between Br?nsted acid moieties of catalyst and nitro group of aromatic alkene were crucial in asymmetric induction. Given the generality, versatility, and high efficiency of this method, we anticipate that it will have broad synthetic utilities.

Regioselective hydrations of 1-aryl-3-en-1-ynes using gold and platinum catalysts: Selective production of 2-en-1-ones and 3-en-1-ones

Regiocontrolled hydrations of 1-aryl-3-en-1-ynes have been accomplished with IPrAuOTf and PtCl2/CO to yield 3-en-1-ones and 2-en-1-ones efficiently; our experimental data indicates that the sizes of catalysts play an important role. This journa

Titanocene(III) chloride mediated reductive cleavage of arylcyclopropyl ketones

Titanocene(III) chloride (Cp2TiCl) mediated cleavage of arylcyclopropyl ketones has been accomplished. Both saturated and β-H eliminated unsaturated aromatic compounds are formed in different ratio depending on the substrate. Ti(III) species has been prepared in situ from commercially available titanocene dichloride (Cp2TiCl2) and zinc dust in THF.