1234908-92-9Relevant academic research and scientific papers
Catalytic Geminal Difluorination of Styrenes for the Construction of Fluorine-rich Bioisosteres
Scheidt, Felix,Neufeld, Jessica,Sch?fer, Michael,Thiehoff, Christian,Gilmour, Ryan
, p. 8073 - 8076 (2018)
A geminal difluorination of alkenes based on I(I)/I(III) catalysis is disclosed, which is compatible with a range of electronically and substitutionally diverse styrenes (27 examples, up to 89% yield). Employing inexpensive p-TolI as the organocatalyst, turnover is enabled by Selectfluor-mediated oxidation to generate the ArIF2 species in situ. Extension to include α-substituted styrenes bearing fluorine-containing groups is disclosed and provides an expansive platform for the generation of fluorine-rich architectures.
Rhodium catalysed enantioselective synthesis of mono-(halo)-methyl-cyclopropanes
Schlinquer, Claire,Huang, Wei-Sheng,Chen, Ling,Poisson, Thomas,Pannecoucke, Xavier,Charette, André B.,Jubault, Philippe
supporting information, p. 472 - 476 (2019/01/24)
The catalytic asymmetric synthesis of mono-fluoro-, -chloro- and -bromomethyl-1,2-diaryl cyclopropane ester is described. The reaction, using Rh2((S)-BTPCP)4 as a catalyst, allowed the formation of the desired cyclopropanes in good to excellent yields (up to 99%) and excellent diastereoselectivities (up to >20:1) and with a high level of enantioselectivities (up to 98% ee). Finally, the synthetic utility of the chiral cyclopropanes was also demonstrated.
Syntheses of mono-, di-, and trifluorinated styrenic monomers
Walkowiak, Justyna,Del Campo, Teresa Martinez,Ameduri, Bruno,Gouverneur, Veronique
experimental part, p. 1883 - 1890 (2010/08/20)
Concise syntheses of gram quantities of three fluorinated -methylstyrenic monomers suitable for polymerisation studies are disclosed, all based on the use of reasonably priced commercially available starting materials and reagents. Georg Thieme Verlag Stuttgart New York.
