1234918-43-4

Upstream product

• 25542-62-5 6-bromo-hexanoic acid ethyl ester 
• 100-83-4 meta-hydroxybenzaldehyde 

Downstream Products

• 1390666-07-5 C₃₅H₄₅NO₅ 
• 1390666-08-6 C₃₄H₄₃NO₅ 
• 1390666-09-7 C₃₇H₄₁NO₅ 
• 1390666-10-0 C₃₈H₄₃NO₅ 
• 1390666-11-1 C₃₂H₃₉NO₅ 
• 1390666-13-3 C₃₃H₃₉NO₆ 
• 1390666-14-4 C₃₃H₄₁NO₆ 
• 1390666-16-6 C₃₁H₃₇NO₅ 
• 1390666-17-7 C₃₂H₃₆F₃NO₅ 
• 1390665-72-1 C₃₂H₃₇NO₆ 
• 1390666-18-8 C₃₂H₃₈FNO₅ 
• 1390666-19-9 C₃₂H₃₈FNO₅ 
• 1390666-20-2 C₃₃H₃₅F₆NO₄ 
• 1390666-21-3 C₃₁H₃₆FNO₄ 

Relevant academic research and scientific papers

CELL IMPERMEABLE COELENTERAZINE ANALOGUES

Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.

Synthesis of Porphyrin-CdSe Quantum Dot Assemblies: Controlling Ligand Binding by Substituent Effects

Cadmium selenide quantum dots of 2.2-2.3 nm diameter were prepared by phosphorus-free methods using oleic acid as stabilizing surface ligand. Ligand exchange monitored quantitatively by 1H NMR spectroscopy gave an estimate of 30-38 monodentate ligands per nanocrystal, with a ligand density of 1.8-2.3 nm-2. The extent of ligand exchange with macrocycles carrying one or more functional groups was investigated, with the aim of producing nanocrystal-macrocycle conjugates with a limited number of coligands. Metal-free porphyrins are able to sequester the Cd2+ ions from the Cd(oleate)2 outer layer of the nanocrystals. Zinc porphyrin complexes carrying one carboxylate function displace oleate efficiently to give porphyrin/CdSe composites with porphyrins stacked upright on the crystal surface. Porphyrins with four potential ligating sites are able to bind to the crystal surface only if the donors are at the end of sufficiently long and flexible tethers. High-dilution methods allowed the synthesis and isolation of well-defined composites of composition [CdSe{porphyrin}2], where porphyrin = 5,10,15,20-tetrakis{3-(carboxy-n-alkyloxy)phenyl}porphyrinato zinc (n = 5 or 10) and 5,10,15,20-tetrakis{3-(11-undecenyloxythiol)phenyl}-porphyrinato zinc. Comparison of the composition data obtained by 1H NMR spectroscopy with luminescence quenching behavior suggests a dependence of quenching efficiency on the tether length. Luminescence quenching was also observed for porphyrins that, according to 1H NMR results, do not undergo surface ligand exchange.

Synthesis and structure-activity relationship of disubstituted benzamides as a novel class of antimalarial agents

Malaria is a devastating world health problem. Using a compound library screening approach, we identified a novel series of disubstituted benzamide compounds with significant activity against malaria strains 3D7 and K1. These compounds represent a new antimalarial molecular scaffold exemplified by compound 1, which demonstrated EC50 values of 60 and 430 nM against strains 3D7 and K1, respectively. Herein we report our findings on the efficient synthesis, structure-activity relationships, and biological activity of this new class of antimalarial agents.